Utility of Europium ion characteristic peak for quantitation of Fenoterol (cas 13392-18-2) hydrobromide and Salmeterol xinafoate in different matrices; application to stability studies

Add time:07/26/2019    Source:sciencedirect.com

A simple selective luminescent dependent approach was established for quantitation of two selective β2 agonists namely; Fenoterol (cas 13392-18-2) hydrobromide (FEN) and Salmeterol xinafoate (SAL). This approach utilizes the capability of the cited drugs to undergo a complexation reaction with Europium ion (Eu3+) in the presence of 1,10-phenanthroline as a co-ligand. The resultant complex leads to a hypersensitive transition and enhancement of the Eu3+ emission peak at 615 nm (279 nm excitation). Under the optimized conditions, the rectilinear concentration plots of both drugs were (70–1500 ng mL−1) and (100–2000 ng mL−1) with limit of quantitation 51.3 and 84.4 ng mL−1 for FEN and SAL, respectively. The luminescence properties of the complex and its optimum formation conditions were carefully investigated according to the regulations of ICH and the method was successfully applied in plasma. The good accuracy and selectivity of the suggested method allowed extending the proposed protocol into stability study of the cited drugs.

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