Ultrasound promoted N-alkylation of pyrrole using Potassium superoxide (cas 12030-88-5) as base in crown ether

Add time:07/28/2019    Source:sciencedirect.com

Ultrasound accelerates the N-alkylation of pyrrole by alkylating reagents using Potassium superoxide (cas 12030-88-5) as base in the presence of 18-crown-6. A much lower yield of N-alkylated pyrrole was realized in the absence of ultrasound. N-alkylating reagents employed for pyrrole are methyl iodide, ethyl bromide, benzyl bromide, as well as acrylonitrile allyl cyanide and methyl acrylate. In an extension of this work, we have found that ultrasound was not necessary for the N-alkylation of indole and alkyl amine, such as diphenyl amine and piperidine with alkyl halides using our reagents. In all cases we observed that the 18-crown-6 catalyzed N-alkylation reaction gives higher yields of N-alkylated products than that without crown ether, when potassium superoxide was used as base. These observations are probably due to the potassium-crown complex which can be released when the reaction goes to completion.

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