Methitural (cas 467-43-6) sodium (Neraval sodium), an intravenous anesthetic for oral surgery procedures

Add time:07/12/2019    Source:sciencedirect.com

Methitural (cas 467-43-6) sodium, a new short-acting thiobarbiturate anesthetic favorable for use in the oral surgery office as an intravenous anesthetic, demonstrates some noticeable advantages in that it shows a lessened recovery time with more complete mental alertness upon recovery. Side effects observed in this short study of only seventy-five cases are not conclusive in view of the fact that such complications as laryngospasms may be produced irrespective of the type of anesthetic used.Since it is our opinion that all short-acting thiobarbiturates being used today can be direct myocardial and respiratory depressants,2 methitural sodium (Neraval sodium) offers among its advantages a slower induction, which is desirable in view of these facts, and the patient awakes faster, which is an advantage in resuscitating the depressed patient.Since the advent and employment of muscle relaxants, surgery is performed in very light planes of anesthesia. In the dental office the routine use of muscle relaxants as an anesthetic adjunct is not practical due to the fact that controlled respiration is somewhat disadvantageous to the operator. Because of the high fat-solubility ratio of methitural sodium, the continuous administration of methitural sodium enables the operator to maintain a light plane of anesthesia with less chance of rapidly overdosing the patient.Methitural sodium seems to be a safe anesthetic agent for dental procedures when administered by qualified and experienced anesthetists. As experience is gained over the years, we will become more familiar with all the advantages and disadvantages of the short-acting thiobarbiturates. As no one antibiotic is sufficient for all infections, no one anesthetic agent will be the panacea for all anesthesia needs.

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