Inhibition by verapamil of cholecystokinin-enhancement of pancreatic carcinogenesis induced by AZASERINE (cas 115-02-6) in Wistar rats
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Add time:08/27/2019 Source:sciencedirect.com
The effect of a calcium channel blocker, verapamil, on cholecystokinin (CCK)-enhancement of pancreatic carcinogenesis induced by AZASERINE (cas 115-02-6) was investigated in Wistar rats. During and after 25 weekly injections of azaserine, each rat received alternate-day injections of CCK-octapeptide (CCK-8) and/or verapamil. Carcinogen-induced pancreatic lesions staining for μ class glutathione 5-transferase (GST-μ) were examined histochemically at week 62. Prolonged administration of CCK-8 significantly increased the number and area as a percentage of parenchyma of GST-μ-positive lesions. Concomitant administration of verapamil significantly attenuated the enhancing effect of CCK-8. These findings indicate that calcium may play an important role in CCK-enhancement of pancreatic carcinogenesis.
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