Attempt towards syn-benzothiazolophane: Synthesis and conformational study of syn-dithia-[3.3](2,6) benzothiazolophane
Synthesis of syn-[2.2](2,6) benzothiazolophane 2 was targeted via oxidative C-C coupling of the key intermediate 7. Compound 7 was synthesized as shown in the Scheme 1. However, several attempts to effect the conversion of 7 to syn-benzothiazolophane 2 fa
Mashraqui, Sabir H.,Kumar, Sukeerthi,Nivalkar, Kishore R.
p. 73 - 78
(2007/10/03)
Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities
In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and
Meyer, Michael D.,Hancock, Arthur A.,Tietje, Karin,Sippy, Kevin B.,Prasad, Rajnandan,Stout, David M.,Arendsen, David L.,Donner, B. Greg,Carroll, William A.
p. 1049 - 1062
(2007/10/03)
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