New short access to pyrrolo[2,3-c]pyridazin-6-ones via β-spirolactams
Treatment of 4-aminoalkyl-2,6-dichloropyridazines with acid chlorides in the presence of triethylamine leads to the formation of β-spirolactams (X-ray confirmed) which subsequently can be transformed into pyrrolo[2,3-c]pyridazin-6-ones. A putative mechani
Stoll, Theodor,Alker, André,Kolczewski, Sabine,Menzi, Andrea,Revil-Baudard, Vincent
p. 772 - 774
(2015/01/30)
Substituted amino-hydrazinopyridazines
Amino and substituted amino-hydrazinopyridazines, e.g., 4-methyl-amino-3-hydrazinopyridazine and 4-ethylamino-6-chloro-3-hydrazinopyridazine, are prepared from 3,4,6-trihalopyridazines and are active as hypotensive/antihypertensive agents.
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(2008/06/13)
Pyridazine derivatives. X. 10H-benzo[b]pyridazino[3,4-e][1,4]thiazine and 5H-benzo[b]pyridazino[4,3-e][1,4]thiazine.
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Yoneda,Ohtaka,Nitta
p. 698 - 706
(2007/10/07)
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