Synthesis and Conformational Studies of Dipeptides Constrained by Disubstituted 3-(Aminoethoxy)propionic Acid Linkers
A series of cyclic compounds with dimethyl-substituted 3-(aminoethoxy)propionic acid linkers have been prepared as potential β-turn mimics. The desired linkers were prepared from disubstituted pyrones, which were coupled with dipeptides and then subjected
Reddy, D. Srinivasa,Vander Velde, David,Aube, Jeffrey
p. 1716 - 1719
(2007/10/03)
7-Methyl-2,3,4,5-tetrahydro-1,4-oxazepin-5-one and the Dioxepinone Analogue: Diastereofacial Selectivity in Catalytic Hydrogenation and the Explanation
Catalytic hydrogenation of the title compound proceeds from the site anti to the 7-methyl group to give the cis-dimethyl derivative; a possible stereoelectronic effect accounting for this selectivity is proposed based on the conformational analysis of the