- From α,α-disubstituted α-aminonitriles to heterocycles: Synthesis of derivatives of 4-amino-29-dihydroisothiazole 1,1-dioxide, a new heterocyclic ring system
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The synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxide (8-10, 12, 15, 16), a new heterocyclic ring system; from α,α-disubstituted α-aminonitriles, is described.
- Marco, Jose L.,Ingate, Simon
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p. 4835 - 4836
(2007/10/03)
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- Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides, the search for linked π-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase
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The synthesis, and anti HIV-1 activity, of new derivatives of 4-amino-1,2-oxathiole 2,2-dioxide (3, 5, 6 and 9) and 4-amino-2,3-dihydroisothiazole 1,1-dioxide (14), a new heterocyclic ring system, is described.
- Ingate, Simon T.,Marco, Jose L.,Witvrouw, Myriam,Pannecouque, Cristophe,De Clercq, Erik
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p. 17795 - 17814
(2007/10/03)
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- Fungicidal N-cyanoalkyl-N-haloalkylthio sulfonamides
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Compounds of the formula: STR1 wherein R is aryl of 6 to 12 carbon atoms or aralkyl of 7 to 14 carbon atoms either optionally substituted with 1 to 3 substituents independently selected from lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, lower alkylsulfinyl of 1 to 6 carbon atoms, lower alkylsulfonyl of 1 to 6 carbon atoms, halogen, trihalomethyl, nitro, cyano or carboxyl; alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or lower alkynyl of 2 to 6 carbon atoms, all optionally substituted with 1 to 3 halogen atoms; lower alkoxyalkylene; lower alkylene carbalkoxy; lower alkylthioalkylene; lower alkylsulfinylalkylene; or lower alkylsulfonylalkylene; R1 and R2 are independently hydrogen, lower alkyl of 1 to 6 carbon atoms, aryl of 6 to 12 carbon atoms, or thienyl, or taken together form an alkylene bridge to give a cycloalkyl group of 3 to 10 carbon atoms; and R3 is alkyl of 1 to 3 carbon atoms substituted with 3 to 6 halogen atoms or trihalovinyl are fungicidal.
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