N-alkylation of imides using phase transfer catalysts under solvent-free conditions
(Chemical Equation Presented) N-Alkylation of imides in the reaction of imides and alkylhalides, catalyzed by PT catalysts under solvent-free conditions, has been developed. The reaction occurs in the presence of K 2CO3, and in many cases it takes place spontaneously. In the N-benzylation reaction, it has been recognized that TBAB (tetrabutylammonium bromide) and TBATFB (tetrabutylammonium tetrafluoroborate) show highest catalytic effect. Versatility and synthetic capacity of the solvent-free alkylation has been confirmed by N-benzylation and N-ethylation of various imides. The developed procedure gives easy access to N-(ω-bromoalkyl) imides.
A simple one-pot synthesis of benzoxazine-2,4-diones and benzothiazine-2,4-diones
A simple and efficient procedure has been developed for a one-pot synthesis of substituted benzoxazine-2,4-diones and benzothiazine-2,4-diones directly from salicylic acid (or thiosalicylic acid) and amines.
Zhu, Xiaoxiang,Yu, Qian-sheng,Greig, Nigel H.,Flippen-Anderson, Judith L.,Brossi, Arnold
p. 115 - 128
(2007/10/03)
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