Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres
Two new APP substrate-based hydroxyethylene isosteres (AT and VI) were prepared and their dipeptide conjugates shown not to inhibit the γ-secretase-mediated formation of either Aβ1-40 or Aβ1-42. The FG isostere and a des-hydroxy hydroxyethylene isostere a
Nadin, Alan,Owens, Andrew P.,Castro, José L.,Harrison, Timothy,Shearman, Mark S.
A practical method for the preparation of α'-chloroketones of N-carbanaate protected-α-aminoacids
A practical method for the preparation of α-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described. This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities.
Chen, Ping,Cheng, Peter T. W.,Spergel, Steven H.,Zahler, Robert,Wang, Xuebao,Thottathil, John,Barrish, Joel C.,Polniaszek, Richard P.
p. 3175 - 3178
(2007/10/03)
Synthesis of peptide chloromethyl ketones and examination of their inhibitory effects on human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE)
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Tsuda,Okada,Nagamatsu,Okamoto
p. 3576 - 3584
(2007/10/02)
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