Aryl- and Alkynyltri-isopropoxytitanium Reagents in Regioselective Carbon-Carbon Bond Formation in Azines
Regioselective arylation in the 4-position in pyridines results from 1:1-adduct formation between an aryltriisopropoxytitanium reagent and N-isobutyloxycarbonyl- or an N-silyloxymethyl-3-cyanopyridinium salt after successive DDQ dehydrogenation and cleavage of the 1-substituent.Complete regioselectivity for new C-C bond formation in the 4-position results in the adduct formation between aryl- and phenylethynyltri-isopropoxytitanium reagents and pyrimidin-2(1H)-ones; with ethynyltriisopropoxytitanium the new C-C bond formation occurs at the 6-position.
Gundersen, Lise-Lotte,Rise, Frode,Undheim, Kjell
p. 5647 - 5656
(2007/10/02)
Structure Investigations on Products from the Reaction of Organocopper, Organolithium and Organomagnesium Reagents with 2(1H)-Pyrimidinones
Alkyl- and arylcuprates and alkyl- and aryllithium and -magnesium reagents form 3,4- or/and 3,6-adducts with 1-benzyl-2(1H)pyrimidinones.The effect of 5-halo substituents on the reactivity and regioselectivity is reported.Structure analyses were made by NMR spectroscopy.Dehydrogenation gives the conjugated, substituted pyrimidinines.X-Ray crystallographic data for 1-benzyl-5-chloro-4-phenyl-2(1H)-pyrimidinone and its regioisomer 1-benzyl-5-chloro-6-phenyl-2(1H)-pyrimidinone are discussed.
Rise, Frode,Romming, Christian,Undheim, Kjell
p. 459 - 468
(2007/10/02)
Regioselectivity in the Reactions of Aryltri-isopropoxytitanium with Pyrimidinones.
Complete regioselectivity is observed in the 1:1-adduct formation between aryltri-isopropoxytitanium reagents and pyrimidin-2(1H)ones: the new carbon-carbon-bond is formed at C-4.Dehydrogenation gives the arylated, fully conjugated heterocycle.
Rise, Frode,Undheim, Kjell
p. 1997 - 2000
(2007/10/02)
More Articles about upstream products of 103594-71-4