- Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis
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The design and synthesis of several novel X-ray contrast agents 1-3, developed for targeting bone structures, and in particularly microcracks in bones, using CT (Computer Tomography) detection is described. These contrast agents are based on the use of the well known triiodobenzene platform, which was conjugated into one or more phenyliminodiacetate moieties, which can be used to 'lock' onto bone matrices. Compounds 1-3 were all tested for their ability to visualise cracks in bone structures (bovine bones) using μ-CT imaging. The Royal Society of Chemistry 2006.
- Parkesh, Raman,Gowin, Wolfgang,Lee, T. Clive,Gunnlaugsson, Thorfinnur
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p. 3611 - 3617
(2008/09/19)
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- Carboxamide non-ionic contrast media
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Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.
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- Non-ionic polyol contrast media from ionic contrast media
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Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
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