Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5- lipoxygenase inhibitors
Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to design selective 5-lipoxygenase (5- LO) inhibitors. Replacement of the NSAID c