- Synthesis and reactivity of highly nucleophilic pyridines
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3,4,5-Triamino-substituted pyridines are avid for electrophiles but are still willing to give them back. In these compounds three amino groups conjoin their forces into the heterocyclic nitrogen, making it a powerful Lewis base. A short and efficient synt
- De Rycke, Nicolas,Berionni, Guillaume,Couty, Francois,Mayr, Herbert,Goumont, Regis,David, Olivier R. P.
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supporting information; experimental part
p. 530 - 533
(2011/03/23)
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- Synthesis and structure of dipyrido-1,4-dithiins
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Synthesis, properties and reactions of two isomeric dipyrido-1,4-dithiins of the C2h and C2v symmetry are described. Their structure determination and identification are based on spectroscopic methods (1H and 13C NMR, HETCOR, gHMBC and MS), physical properties (mp and Rf), the 1,4-dithiin ring opening reactions and finally X-Ray analysis. A very unusual type of the Smiles rearrangement (S→S, the pyridyl group migrates from one sulfur atom to another) during the 1,4-dithiin ring opening with sodium methanethiolate enabling isomerization of dithiin with the C2h symmetry to dithiin with the C2v symmetry is found.
- Morak, Beata,Pluta, Krystian,Suwinska, Kinga,Grymel, Miroslawa,Besnard, Celine,Schiltz, Marc,Kloc, Christian,Siegrist, Theo
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p. 2619 - 2634
(2007/10/03)
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- Anti-inflammatory oxazole[4,5-b]pyridines
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The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
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