A practical and cost-efficient, one-pot conversion of aldehydes into nitriles mediated by 'activated DMSO'
Participation of activated DMSO in the one-pot transformation of aldehydes to nitriles has been described by reacting aldehydes with NHHHCl in DMSO in the absence of any added base or catalyst. The method is applicable to access a wide range of aromatic, heterocyclic, and aliphatic nitriles, in which only water is a byproduct. A straightforward and practical procedure is demonstrated on a multigram scale. Georg Thieme Verlag Stuttgart - New York.
Augustine, John Kallikat,Bombrun, Agnes,Atta, Rajendra Nath
scheme or table
p. 2223 - 2227
(2011/10/31)
Process for the preparation of 2,3-difluorobenzenes
1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.
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(2008/06/13)
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