- OLEIC ACID DERIVATIVES AS TREATMENTS FOR FRIEDREICH ATAXIA AND INHIBITORS OF FERROPTOSIS
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The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurdegenerative disorders, such as Friedreich ataxia.
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Paragraph 00166
(2021/05/21)
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- Production of Valuable Esters from Oleic Acid with a Porous Polymeric Acid Catalyst without Water Removal
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We demonstrate the use of porous phenolsulfonic acid-formaldehyde (PSF) resins as solid-acid catalysts, which showed excellent performance in the esterification of fatty acids without using any solvent or introducing a water-removal process. The catalyst was reused up to 30 times without significant loss of activity.
- Kim, Yo-Han,Han, Jusung,Jung, Byeong Yeon,Baek, Heeyoel,Yamada, Yoichi M. A.,Uozumi, Yasuhiro,Lee, Yoon-Sik
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supporting information
p. 29 - 32
(2015/12/26)
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- Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against mycobacterium tuberculosis
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Eleven fatty acid analogues incorporating four-membered carbocycles (cyclobutenes, cyclobutanes, cyclobutanones, and cyclobutanols) were investigated for the ability to inhibit the growth of Mycobacterium smegmatis (Msm) and Mycobacterium tuberculosis (Mtb). A number of the analogues displayed inhibitory activity against both mycobacterial species in minimal media. Several of the molecules displayed potent levels of inhibition against Mtb, with MIC values equal to or below those observed with the anti-tuberculosis drugs D-cycloserine and isoniazid. In contrast, two of the analogues that display the greatest activity against Mtb failed to inhibit E. coli growth under either set of conditions. Thus, the active molecules identified herein may provide the basis for the development of anti-mycobacterial agents against Mtb.
- Sittiwong, Wantanee,Zinniel, Denise K.,Fenton, Robert J.,Marshall, Darrell D.,Story, Courtney B.,Kim, Bohkyung,Lee, Ji-Young,Powers, Robert,Barletta, Raúl G.,Dussault, Patrick H.
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supporting information
p. 1838 - 1849
(2014/08/18)
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- AMPHIPHILIC CYCLOBUTENES AND CYCLOBUTANES
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This disclosure relates to amphiphilic compounds containing a cyclobutene or cyclobutane moiety. In some embodiments, the compounds are useful for treating infection by Mycobacterium such as Mycobacterium tuberculosis. Cyclobutene containing compounds are also useful as monomers in the preparation of amphiphilic polymers.
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Page/Page column 44
(2014/01/07)
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- 5,5′-Dimethyl-3,3′-azoisoxazole as a new heterogeneous azo reagent for esterification of phenols and selective esterification of benzylic alcohols under Mitsunobu conditions
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5,5′-Dimethyl-3,3′-azoisoxazole is used as a new efficient heterogeneous azo reagent for the highly selective esterification of primary and secondary benzylic alcohols and phenols with aliphatic and aromatic carboxylic acids via Mitsunobu protocols. The reaction is highly selective for primary benzylic alcohols versus secondary ones, aliphatic alcohols and also phenols. The isoxazole hydrazine byproduct can be simply isolated by filtration and recycled to its azoisoxazole by oxidation.
- Iranpoor, Nasser,Firouzabadi, Habib,Khalili, Dariush
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supporting information; experimental part
p. 4436 - 4443
(2010/11/05)
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- Esterification of carboxylic acids with alcohols under microwave irradiation in the presence of zinc triflatet
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The esterification of aliphatic and aromatic carboxylic acids with various alcohols (1°, 2°, 3°, benzylic) was studied under microwave irradiation in the presence of zinc triflate as catalyst; the reaction times were short and the yield of reactions was good to excellent.
- Shekarriz, Marzieh,Taghipoor, Sohrab,Khalili, Ali Asghar,Jamarani, Mohammad Soleymani
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p. 172 - 173
(2007/10/03)
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- Efficient conversion of vicinal diols to alkenes by treatment of the corresponding dimesylates with a catalytic, minimally fluorous, recoverable diaryl diselenide and sodium borohydride
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(Matrix presented) In conjunction with sodium borohydride as stoichiometric reagent a catalytic quantity of bis(4-perfluorohexylphenyl) diselenide converts vicinal dimesylates to the corresponding alkenes in good yield on warming in ethanol. The diselenide is recovered in high yield by continuous fluorous extraction.
- Crich, David,Neelamkavil, Santhosh,Sartillo-Piscil, Fernando
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p. 4029 - 4030
(2007/10/03)
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- Synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides by reaction of 5′-protected nucleoside 2′,3′-dimesylates with telluride dianion: A general route from cis vicinal diols to olefins
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2′,3′-Dimesylates of 5′-protected nucleosides are converted into the corresponding 2′,3′-didehydro2′,3′-dideoxy compounds by treatment with telluride dianion in the form of the sodium or lithium salt. The method is well-suited to the preparation of unsaturated nucleosides that can be converted into compounds that are believed to be useful in the treatment of AIDS. The deoxygenation is general for vicinal dimesylates that have, or may adopt, a synperiplanar conformation. With straight chain compounds the reaction is stereospecific. In some cases, similar, but slower, deoxygenations can be performed with selenide dianion.
- Clive, Derrick L. J.,Wickens, Philip L.,Sgarbi, Paulo W. M.
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p. 7426 - 7437
(2007/10/03)
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