- A 2, 6 - two ethyl aniline cogeneration O-ethyl aniline synthesis device
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A 2, 6 - two ethyl aniline cogeneration O-ethyl aniline synthesis device, comprises a prepares the cauldron, reactor, the prepares the cauldron the left side wall of the lower end of the discharge hole is set A, prepares the cauldron arranged on the wall of the lower end of the discharge port of the right side of B, prepares the cauldron arranged at the center of the lower end of the discharge port C, arranged at the top end of the reactor feed inlet, a feed opening provided with a always loses pipe, discharge port A, B the discharge port, the discharge port are arranged on the conveying pipe C, A the discharge port, the discharge port B, on the C of the conveyor through the discharge port are connected with the total of the conveying pipe, the discharge port A, B the discharge port, the discharge port is connected to the C are installed on all of the conveyor through the discharge valve, the discharge port A mounting used for preparing high cauldron always sinusodial form, discharge port B installed at high three-quarters of the preparation cauldron always, reduces the 2, 6 - two ethyl benzenes later rectification cost, improves the overall yield of the alkylation, can meet the external clients 2, 6 - diethyl aniline high demand of content.
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Paragraph 0013-0019
(2017/06/15)
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- Regioselectivity of the ortho- and para-semidine, and diphenyline rearrangements
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The regioselectivity of the o-semidine, p-semidine, and diphenyline rearrangements of unsymmetrical N,N′-diarylhydrazines was studied experimentally. The results indicate that their electron-rich nitrogen atom is first protonated and then the electron-poor non-protonated nitrogen atom undergoes an N[1,3]-sigmatropic shift to the ortho-position of the electron-rich aryl rings, generating key intermediates. The intermediates can undergo (1) a direct proton transfer to give o-semidines, (2) a second N[1,3]-shift of the electron-poor nitrogen atom and then proton transfer to furnish p-semidines, and (3) a [3,3]-sigmatropic shift and subsequent proton transfer to yield diphenylines. It is the first N[1,3]-sigmatropic shift step that plays an important role in controlling the regioselectivity in the three rearrangements, further determining the structures of o-semidines, p-semidines, and diphenylines. The current results provide new insights into the o/p-semidine and diphenyline rearrangements and useful information for controlling and predicting the structures of the rearrangement products.
- Yang, Zhanhui,Hou, Shili,He, Wei,Cheng, Baoxiang,Jiao, Peng,Xu, Jiaxi
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p. 2186 - 2195
(2016/04/09)
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- Chemoselective N-deacetylation under mild conditions
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A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.
- Sultane, Prakash R.,Mete, Trimbak B.,Bhat, Ramakrishna G.
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supporting information
p. 261 - 264
(2014/01/06)
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- A new sensitive spectrophotometric determination of butachlor
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A new sensitive spectrophotometric method was developed for the determination of widely used herbicide butachlor. The method is based on acidic hydrolysis of butachlor to 2, 6-diethyl amine, followed by coupling with diazotized aniline in acidic medium. The absorption maxima of the orange dye compound formed was measured at 490 nm. Beer's law was obeyed over the concentration range of 10-40 μg (0.1 ppm to 0.4 ppm) in a final solution volume of 10 mL. The molar absorptivity, Sandell's sensitivity and correlation coefficient were found to be 7.07×102 L mol-1 cm-1 , 0.20 μg cm-2 and 0.963 respectively. The standard deviation and relative standard deviation were found to be ±0.009 and 1.98% respectively. The method was simple sensitive and free from interferences of other pesticide and diverse ions. The method was successfully applied to the determination of butachlor in environmental and biological samples.
- Khatoon, Raisa,Rai, Manish Kumar,Patel, Vindhiya,Rai, Joyce
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p. 1059 - 1063
(2015/01/30)
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- N[1,3]-sigmatropic shift in the benzidine rearrangement: Experimental and theoretical investigation
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The N[1,3]-sigmatropic shift in the benzidine rearrangement has been studied in depth experimentally with the aid of density functional theory (DFT) calculations. The designed substituted N,N′-diaryl hydrazines rearrange exclusively to the expected o/p-semidines and diphenylines. Intercrossing experiments support the intramolecular rearrangement process. Radical trapping experiments exclude the intermediacy of biradicals in the rearrangements. Computational results demonstrate that the o-semidine rearrangement involves a novel N[1,3]-sigmatropic shift and the p-semidine rearrangement proceeds via tandem N[1,3]/N[1,3]-sigmatropic shifts, while the diphenyline rearrangement occurs through cascade N[1,3]/[3,3]-sigmatropic shifts. The proposed mechanism involving the key N[1,3]-sigmatropic shift as the rate-limiting step is in good agreement with reported kinetic isotope measurements. The combined methods provide new insight into the formation mechanism of o/p-semidines and diphenylines in the benzidine rearrangement and support the unprecedented suprafacial symmetry allowed N[1,3]-sigmatropic shift with an inversion of the configuration in the migrating nitrogen atom. This journal is the Partner Organisations 2014.
- Hou, Shili,Li, Xinyao,Xu, Jiaxi
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supporting information
p. 4952 - 4963
(2014/07/07)
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- Steric hindrance as a key factor on proton transfer in the σ-adduct forming reactions of o-substituted anilines with 1,3,5-trinitrobenzene in dimethylsulfoxide
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Kinetic and equilibrium studies are reported of the reactions of 1,3,5-trinitrobenzene (TNB) with a series of o-substituted anilines in dimethyl sulfoxide (DMSO) in the presence of 1,4-diazabicyclo[2.2.2.]octane (DABCO). The pKa values in DMSO for the aniline derivatives were measured using the proton-transfer equilibrium with 2,4-dinitrophenol. Kinetic studies are compatible with a two-step process involving initial nucleophilic attack on TNB by amine to give a zwitterionic intermediate which may transfer an acidic proton to DABCO to yield the anionic product. The results indicate steric hindrance to proton transfer in reactions involving 2,6-disubstituted anilines.
- Asghar, Basim H.
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scheme or table
p. 1191 - 1195
(2009/12/03)
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- Halide-free ethylation of phenol by multifunctional catalysis using phosphinite ligands
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The ortho-alkylation of phenols or aniline by catalytic C-H activation and multifunctional catalysis is described. The Royal Society of Chemistry 2006.
- Carrion, M. Carmen,Cole-Hamilton, David J.
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p. 4527 - 4529
(2008/09/18)
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- Stilbene derivative and method for producing the same
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The present invention provides a novel stilbene derivative represented by the general formula (1): STR1 wherein R1 and R3 represent an alkyl group, an aryl group, an aralkyl group or an alkoxy group which are optionally substituted; and R2 and R4 represent a hydrogen atom, an alkyl group or an alkoxy group which are optionally substituted, provided that when the substitution position of R2 and R4 is the 4-(para) position, R2 and R4 are hydrogen atoms, a method for producing the same and use thereof. The above stilbene derivative (1) is useful as an electric charge transferring material, particularly hole transferring material.
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- Linear dicarbonylation of difunctionalized butenes
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Difunctional butenes are linearly dicarbonylated into 3-hexene-1,6-dioic acid or alkyl diesters thereof, well suited for the ultimate production of, e.g., adipic acid, by reacting such difunctional butene with carbon monoxide and, if appropriate, an alcohol, at an elevated temperature under superatmospheric pressure, in the presence of at least one source of hydrogen chloride and a catalytically effective amount of palladium, at least a portion of which palladium being in the zero oxidation state, as well as a quaternary onium chloride of nitrogen or phosphorus, the nitrogen or phosphorus atom being tetracoordinated to carbon atoms, with the proviso that the nitrogen atom may be coordinated to two pentavalent phosphorus atoms.
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- A NEW RADICAL REACTION IN THE SERIES OF SCHIFF BASES. ARYLATION OF SCHIFF BASES BY NITROSOACETANILIDE
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The radical arylation of schiff bases with nitrosoacetanilide was realized.The addition of the aryl radical takes place regioselectively at the imidyl carbon atom of the azomethine.
- Terent'ev, A. B.,Yashkina, L. V.,Pastushenko, E. V.,Kruglov, D. E.,Safiulova, G. I.
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p. 807 - 809
(2007/10/02)
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- 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics
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A novel method of controlling epilepsy, muscle tension, muscular spasticity, and anxiety in living animal bodies by administering compounds of the formula: STR1 wherein: R1 is hydrogen, loweralkyl or a pharmaceutically acceptable cation; R2 and R3, same or different, are hydrogen, loweralkyl, aryl, cycloalkyl, loweralkenyl, 1-adamantyl, heterocyclicaminoalkyl, diloweralkylaminoloweralkyl, or R2 with R3 and adjacent nitrogen may form a heterocyclic ring structure; and the pharmaceutical acceptable acid salts, and tautomeric isomers thereof; and novel pharmaceutical compositions therefor are disclosed.
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- Revisitation of Formaldehyde Aniline Condensation. VIII. - Monomeric N-Methylene Anilines
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A convenient, high yield "dry" method of synthesis of monomeric N-methyleneanilines (6a-i) and the characterization of the products by m.s., 1H- and 13C-n.m.r. and i.r. are reported, improving previous procedures and describing new compounds.It appeared that the existence of monomeric N-methyleneanilines is stricly related to the presence of enough steric hindrance to oligomerization by substituents in ortho positions.Moreover, some addition products of formaldehyde to an amine and its corresponding imines are tentatively identified on the basis of the observed mass spectrum of the whole reaction mixture.The reaction products of formaldehyde with 2,6-dimethylaniline (1a) provided an example of a mobile equilibrium between monomeric and trimeric imine.
- Giumanini, Angelo G.,Verardo, Giancarlo,Polana, Marco
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p. 161 - 174
(2007/10/02)
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- New diamines and a process for their production
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New aminoalkyl anilines having the formula: STR1 wherein k is 0 or 1; QNH2 is a residue of formula STR2 which is situated in one of the positions of the benzene ring ortho or para to the amino group and wherein n is an integer from 1 to 15, R1 is C1 -C8 alkyl, R2 is C1 -C4 alkyl or R1 and R2, together with the carbon atom to which they are attached, form a C5 -C8 cycloalkylene residue, R3 is H or C1 -C6 alkyl, C3 -C8 cycloalkyl, or C6 -C10 aryl; and R4 and R5 are H or C1 -C4 alkyl; as well as the corresponding salts of compounds of formula I with organic or inorganic acids and metal salt complexes; process for their production; and their use as intermediates for polyamides.
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- Non Conventional Syntheses of Heterocyclic Compounds. 3. Synthesis of Indazole Derivatives
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The thermal cyclization of a few 2,6-dimethylphenylazo compounds to indazole derivatives is described.
- Fusco, Raffaello,Marchesini, Alessandro,Sannicolo, Franco
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p. 773 - 778
(2007/10/02)
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- Preparation of aromatic amines
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Aromatic amines (anilines) are obtained directly or via the corresponding cycloaliphatic amines by an aminating/hydrogenating reaction of phenols with ammonia and hydrogen over a supported palladium catalyst which also contains elements from group 1b, 2b or 7b of the periodic table as well as iron, cobalt or nickel, as such or in the form of their compounds, and, preferably, an inorganic base, said catalysts also having dehydrogenating properties.
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