- Efficient method for synthesis of angucyclinone antibiotics via gold-catalyzed intramolecular [4 + 2] benzannulation: Enantioselective total synthesis of (+)-ochromycinone and (+)-rubiginone B2
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An efficient synthetic approach to angucyclinone antibiotics, (+)-ochromycinone and (+)-rubiginone B2, is reported. The key step involves the facile formation of 2,3-dihydrophenantren-4(1H)-one skeleton, an important framework of angucyclinone
- Sato, Kenichiro,Asao, Naoki,Yamamoto, Yoshinori
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p. 8977 - 8981
(2007/10/03)
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- An efficient, simple and inexpensive method for the preparation of 1,4-benzoquinone monoketals via anodic oxidation of 1,4-dimethoxybenzenes
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Anodic oxidation of a series of 1-substituted-2,5-dimethoxybenzenes gives 2-substituted-1,1,4,4-tetramethoxycyclohexa-2,5-dienes in almost quantitative crude yield. Selective monohydrolysis of these bis-ketals is possible in many cases, and gives 3-substi
- Gautier,Lewis,McKillop,Taylor
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p. 2989 - 3008
(2007/10/02)
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- Anodic Oxidation of 1,4-Dimethoxy Aromatic Compounds. A Facile Route to Functionalized Quinone Bisketals.
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The anodic oxidation of 12 functionalized 1,4-dimethoxybenzene derivatives and 8 functionalized 1,4-dimethoxynaphthalenes has been studied under a variety of conditions.Many substituted 1,4-dimethoxy aromatics afford high yields of the respective quinone bisketals by single-cell anodic oxidation without accurate control of the electrode potential.Oxidizable groups offen complicate the anodic oxidation; however, in some cases protected derivatives of these functionalities can be converted to the bisketals in good yields.Aromatics containing reducible functions can besmoothly oxidized to quinone bisketals by the use of a divided cell.The current efficiencies and the effect of electrode material on selected systems are reported and discussed.
- Henton, Daniel R.,McCreery, Richard L.,Swenton, John S.
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p. 369 - 378
(2007/10/02)
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