- Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
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Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show select
- Walter, Anne,Chaikuad, Apirat,Helmer, Renate,Loa?c, Nadège,Preu, Lutz,Ott, Ingo,Knapp, Stefan,Meijer, Laurent,Kunick, Conrad
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- MACROCYCLIC KINASE INHIBITORS
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Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.
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Page/Page column 64
(2012/06/16)
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- PYRIMIDINE DERIVATIVES
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Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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Page/Page column 83; 84
(2008/06/13)
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