- Transition-Metal-Free Synthesis of Homo- and Hetero-1,2,4-Triaryl Benzenes by an Unexpected Base-Promoted Dearylative Pathway
-
An unprecedented approach for the synthesis of homo- and hetero-1,2,4-triaryl benzenes has been developed using a simple base-mediated reaction of either α-aryl cinnamyl alcohols or α,γ-di-aryl propanones. The salient feature of this strategy involves the sequential hydride transfer, regiospecific condensation, regiospecific dearylation, and aromatization under metal-free reaction conditions. The synthesis of unsymmetrically substituted triphenylenes by oxidative coupling of the synthesized 1,2,4-triaryl benzenes has also been demonstrated.
- Rehan, Mohammad,Maity, Sanjay,Morya, Lalit Kumar,Pal, Kaushik,Ghorai, Prasanta
-
supporting information
p. 7728 - 7732
(2016/07/07)
-
- Synthesis and crystal structures of (E)-1-Phenyl-3-[(2,4,6-Trimethylphenyl) ]prop-2-En-1-One and (E)-1-Phenyl-3-[(4-Trifluoromethylphenyl)]prop-2-En-1-One
-
Two chalcone compounds, namely (E)-1-phenyl-3-[(2,4,6-trimethylphenyl)] prop-2-en- 1-one (1) and (E)-1-phenyl-3-[(4-trifluoromethylphenyl)]prop-2-en-1- one (2), have been synthesized and structurally characterized by elemental analysis, 1H NMR
- Liu, Yun-Feng,Liang, Wen-Jun,Zhao, Pei-Hua,Li, Xin-Hang,Liu, Sheng-Nan,Liu, Ya-Qing
-
p. 253 - 260
(2014/07/07)
-
- Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia
-
A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen-Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC50 values were 12.72, 15.05 and 15.31 μg/mL, respectively; these are potential leads for the development of antigiardial compounds.
- Montes-Avila, Julio,Diaz-Camacho, Sylvia P.,Sicairos-Felix, Josefina,Delgado-Vargas, Francisco,Rivero
-
experimental part
p. 6780 - 6785
(2009/12/06)
-