- THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
-
Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
- -
-
Paragraph 0538
(2020/12/11)
-
- ORGANIC COMPOUNDS
-
New compounds of the Formula (I) for the treatment of non-insulin-dependent diabetes mellitus.
- -
-
Page/Page column 126-127
(2008/06/13)
-
- Bisaryl-sulfonamides
-
Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ or PPARδ. In particular, the compounds of the invention modulate the function of PPARγ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
- -
-
Page/Page column 29
(2008/06/13)
-