- Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
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The nonribosomal enterotoxin tilivalline was the first naturally occurring pyrrolobenzodiazepine to be linked to disease in the human intestine. Since the producing organism Klebsiella oxytoca is part of the intestinal microbiota and the pyrrolobenzodiaze
- Dornisch, Elisabeth,Pletz, Jakob,Glabonjat, Ronald A.,Martin, Florian,Lembacher-Fadum, Christian,Neger, Margit,H?genauer, Christoph,Francesconi, Kevin,Kroutil, Wolfgang,Zangger, Klaus,Breinbauer, Rolf,Zechner, Ellen L.
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p. 14753 - 14757
(2017/11/14)
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- Metallo-β-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem
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3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4′-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
- Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
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p. 5841 - 5850
(2013/09/12)
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- 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
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Provided are 4'-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
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- Mono- and dihydroxylated metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity
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Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide.
- Nakamura, Takanori,Noguchi, Tomomi,Kobayashi, Hisayoshi,Miyachi, Hiroyuki,Hashimoto, Yuichi
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p. 1709 - 1714
(2007/10/03)
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- Total synthesis of enantiomerically pure (-)-Balanol
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The total synthesis of enantiomerically pure (-)-Balanol (1), using tri-O-acetyl-D-glucal as a chiral template for the central azepane fragment is described.
- Barbier, Pierre,Stadlwieser, Josef
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p. 530 - 532
(2007/10/03)
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