109183-71-3 Usage
Description
Boc-L-Cyclohexylglycine, also known as N-Boc-2-cyclohexyl-L-glycine, is a chemical compound that appears as a white powder. It is a derivative of L-Cyclohexylglycine with a Boc (tert-butyloxycarbonyl) protecting group attached to the nitrogen atom. This modification enhances the stability and reactivity of the molecule, making it suitable for various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Boc-L-Cyclohexylglycine is used as a pharmaceutical intermediate for the synthesis of various drugs and bioactive compounds. Its unique structure and properties allow it to be incorporated into the development of new medications with potential therapeutic benefits.
Used in Hepatitis C Treatment:
Boc-L-Cyclohexylglycine has been utilized as a reactant in the preparation of a potent hepatitis C protease inhibitor. This inhibitor plays a crucial role in the treatment of hepatitis C by targeting and inhibiting the activity of the viral protease enzyme, which is essential for the replication of the virus. By inhibiting this enzyme, the replication of the virus is halted, leading to a reduction in viral load and improvement in the patient's condition.
Check Digit Verification of cas no
The CAS Registry Mumber 109183-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,1,8 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 109183-71:
(8*1)+(7*0)+(6*9)+(5*1)+(4*8)+(3*3)+(2*7)+(1*1)=123
123 % 10 = 3
So 109183-71-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H23NO4/c1-13(2,3)18-12(17)14(9-11(15)16)10-7-5-4-6-8-10/h10H,4-9H2,1-3H3,(H,15,16)
109183-71-3Relevant articles and documents
Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors
Choi, Jun Yong,Fuerst, Rita,Knapinska, Anna M.,Taylor, Alexander B.,Smith, Lyndsay,Cao, Xiaohang,Hart, P. John,Fields, Gregg B.,Roush, William R.
, p. 5816 - 5825 (2017)
We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative
Enantioselective Synthesis of Dialkylated α-Hydroxy Carboxylic Acids through Asymmetric Phase-Transfer Catalysis
Duan, Shaobo,Li, Sanliang,Ye, Xinyi,Du, Nuan-Nuan,Tan, Choon-Hong,Jiang, Zhiyong
supporting information, p. 7770 - 7778 (2015/08/18)
In the presence of an L-tert-leucine-derived urea-ammonium salt as phase-transfer catalyst, a highly enantioselective alkylation of 5H-oxazol-4-ones with various benzyl bromides and allylic bromides has been developed to furnish catalytic asymmetric synthesis of biologically important dialkylated α-hydroxy carboxylic acids with a broad scope. This is the first example of an L-amino acid-derived urea-ammonium salt being used as a phase-transfer catalyst with excellent catalytic efficiency.
PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS
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Page/Page column 136-137, (2011/12/04)
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R, R2, and R3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.