118156-93-7

Basic information

• Product Name: 1-BOC-3-PIPERIDINECARBOXALDEHYDE
• Synonyms: N-BOC-3-PIPERIDINYLCARBOXALDEHYDE;N-BOC-3-FORMYLPIPERIDINE;BOC-3-PIPERIDINECARBOXALDEHYDE;BUTTPARK 147\06-01;1-BOC-3-PIPERIDINECARBOXALDEHYDE;1-N-BOC-3-FORMYLPIPERIDINE;3-FORMYLPIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-3-formylpiperidine
• CAS NO: 118156-93-7
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27
• Product Categories: pharmacetical;Piperidine
• Mol File: 118156-93-7.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 295.4 °C at 760 mmHg
• Flash Point: 132.5 °C
• Appearance: /
• Density: 1.114 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.29±0.40(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-BOC-3-PIPERIDINECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-3-PIPERIDINECARBOXALDEHYDE(118156-93-7)
• EPA Substance Registry System: 1-BOC-3-PIPERIDINECARBOXALDEHYDE(118156-93-7)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-50-36-22
• Safety Statements: 26-36/37/39-61-37
• RIDADR: UN3077
• Hazardous Substances Data: 118156-93-7(Hazardous Substances Data)

Usage

Description

1-BOC-3-PIPERIDINECARBOXALDEHYDE, also known as N-Boc-3-piperidinecarboxaldehyde, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its colorless liquid appearance and plays a significant role in the development of new compounds with potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
1-BOC-3-PIPERIDINECARBOXALDEHYDE is used as an organic chemical synthesis intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the creation of a wide range of drugs with potential therapeutic applications, including those targeting central nervous system disorders, pain management, and other medical conditions.
Used in Chemical Industry:
1-BOC-3-PIPERIDINECARBOXALDEHYDE is also utilized as a key intermediate in the synthesis of various chemicals, such as agrochemicals, dyes, and other specialty chemicals. Its versatility in chemical reactions enables the production of a diverse array of products with specific properties and applications in different sectors.

InChI:InChI=1/C11H19NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h8-9H,4-7H2,1-3H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 116574-71-1 (±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate 
• 7529-22-8 4-methylmorpholine N-oxide 
• 4606-65-9 3-(hydroxymethy)piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114615-82-6 tetrapropylammonium perruthennate 
• 498-95-3 nipecotic acid 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 189442-78-2 (±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 

Downstream Products

• 406212-53-1 tert-butyl 3-{2-amino-6-[2-(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 406212-57-5 tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 744216-05-5 2'-amino-6'-(2-benzyloxy-phenyl)-1,2,3,4,5,6-hexahydro-[3,4']bipyridinyl-3'-carbonitrile 
• 744216-06-6 2'-amino-6'-(2-benzyloxy-phenyl)-1-methyl-1,2,3,4,5,6-hexahydro-[3,4']bipyridinyl-3'-carbonitrile 
• 406212-54-2 tert-butyl 3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]-1-piperidinecarboxylate 
• 744216-09-9 3'-cyano-6'-(2-hydroxy-phenyl)-2'-methylamino-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 406212-70-2 2'-acetylamino-3'-cyano-6'-(2-hydroxy-phenyl)-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

(E) and (Z)-3-styrylpiperidines as sigma ligands

A class of (E) and Q-3-styrylpiperidine derivatives was prepared as racemates and evaluated for affinity at σ binding sites labeled with [3H]-(±-SKF-10,047. Some of these compounds exhibited high affinity and selectivity for σ verus D1 and D2 binding sites.

Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1 H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia

BCR-ABL kinase inhibition is an effective strategy for the treatment of chronic myeloid leukemia (CML). Herein, we report compound 3a-P1, bearing a difluoro-indene scaffold, as a novel potent pan-inhibitor against BCR-ABL mutants, including the most refractory T315I mutant. As the privileged (S)-isomer compared to its (R)-isomer 3a-P2, 3a-P1 exhibited potent antiproliferative activities against K562 and Ku812 CML cells and BCR-ABL and BCR-ABLT315I BaF3 cells, with IC50 values of 0.4, 0.1, 2.1, and 4.7 nM, respectively. 3a-P1 displayed a good safety profile in a battery of assays, including single-dose toxicity, hERG K+, and genotoxicity. It also showed favorable mice pharmacokinetic properties with a good oral bioavailability (32%), a reasonable half-life (4.61 h), and a high exposure (1386 h·ng/mL). Importantly, 3a-P1 demonstrated a higher potency than ponatinib in a mice xenograft model of BaF3 harboring BCR-ABLT315I. Overall, the results indicate that 3a-P1 is a promising drug candidate for the treatment of CML to overcome the imatinib-resistant T315I BCR-ABL mutation.

A kind of protease inhibitor and its preparation and use

The invention discloses a kind of protease inhibitors, and preparation method and application thereof. The invention discloses a kind of compounds and pharmaceutical compositions thereof, and a preparation method and application thereof. The invention relates to a kind of compounds capable of reducing or inhibiting activity of dual leucine zipper kinase in cells or a subject, and application of the compounds, or solvates, hydrates or medicinal salts thereof to prevent or treat patient diseases or related diseases caused by abnormity of dual leucine zipper kinase.