135206-87-0

Basic information

• Product Name: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-
• CAS NO: 135206-87-0
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Mol File: 135206-87-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(135206-87-0)
• EPA Substance Registry System: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(135206-87-0)

Safety Data

• Hazardous Substances Data: 135206-87-0(Hazardous Substances Data)

Usage

General Description

"Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-, also known as (R)-(-)-4-Hydroxy-4-(morpholin-4-yl)butan-2-one, is a complex organochemical compound. Being a derivative of the heterocyclic compound morpholine, it contains constituent elements such as nitrogen and oxygen and belongs to the chemical class of Morpholines. It exhibits optical activity and is commonly represented under the CAS registry number 101200-75-3. The compound is known for its structural features that include the presence of an alpha, beta-unsaturated carbonyl moiety. Various scientific researches are conducted involving this compound, mostly in analytical chemistry and pharmacology."

Upstream product

• 110-91-8 morpholine 
• 17392-83-5 (R)-Methyl lactate 
• 141-78-6 ethyl acetate 
• 547-64-8 methyl lactate 

Downstream Products

• 900183-29-1 4-{(2R)-2-[(3-bromobenzyl)oxy]propanoyl}morpholine 
• 247196-89-0 (R)-2-benzyloxypropionyl N-morpholinyl amide 
• 940009-00-7 2-chloro-4-({5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]quinazolin-4-yl}amino)phenol 
• 900183-42-8 4-((2R)-2-{[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)benzyl]oxy}propanoyl)morpholine 
• 502481-65-4 methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate 
• 502481-63-2 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene 
• 502481-64-3 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylaniline 
• 502481-62-1 2-((S)-1-morpholinocarbonylethoxy)-4-hydroxymethylnitrobenzene 
• 474010-01-0 N-((2R)-2-p-toluenosulfonyloxypropanoyl)morpholine 
• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 

Relevant articles and documents

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

A PROCESS FOR THE PREPARATION OF ISAVUCONAZOLE AND ITS INTERMEDIATES

The present invention relates to a process for the preparation of Isavuconazole or its pharmaceutical acceptable salt thereof. In particular aspects of the present invention relates to a process for the preparation of intermediate of azole intermediate. In a further aspect, the present invention relates to a process for the preparation of triazole intermediate. In a further aspect, the present invention relates to a process for the preparation of oxirane intermediate.

The process development of ravuconazole: An efficient multikilogram scale preparation of an antifungal agent

The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.