145484-45-3

Basic information

• Product Name: 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R*,S*)]-(9CI)
• Synonyms: 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R*,S*)]-(9CI);(aS,?3R)?-3-?[[(9H-?Fluoren-?9-?ylmethoxy)carbonyl]?amino]?-?α-?(2-?methylpropyl)?-?2-?oxo-?1-?pyrrolidineacetic acid;Fmoc-Freidinger's lactam≥ 97% (HPLC)
• CAS NO: 145484-45-3
• Molecular Formula: C25H28N2O5
• Molecular Weight: 436.5
• Product Categories: FMOC
• Mol File: 145484-45-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 682.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: Store at 0-5°C
• PKA: 3.78±0.21(Predicted)
• CAS DataBase Reference: 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R*,S*)]-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R*,S*)]-(9CI)(145484-45-3)
• EPA Substance Registry System: 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R*,S*)]-(9CI)(145484-45-3)

Safety Data

• Hazardous Substances Data: 145484-45-3(Hazardous Substances Data)

Usage

Description

1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R,S)]-(9CI) is a complex organic compound with a unique molecular structure. It is characterized as a white amorphous powder and is known for its dipeptide peptidomimetic properties, specifically for the Gly-Val sequence. 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R,S)]-(9CI) also has a connection to Fmoc-Freidinger's lactam, which is an important intermediate in the synthesis of various peptides and peptidomimetics.

Uses

Used in Pharmaceutical Industry:
1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R,S)]-(9CI) is used as a dipeptide peptidomimetic for the development of pharmaceutical compounds targeting the Gly-Val sequence. Its unique structure allows for the creation of novel drugs with potential applications in various therapeutic areas.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R,S)]-(9CI) serves as a key intermediate in the synthesis of Fmoc-Freidinger's lactam. This lactam is crucial for the development of various peptides and peptidomimetics, which have a wide range of applications in the pharmaceutical, biotechnological, and materials science industries.
Used in Research and Development:
Due to its unique structure and properties, 1-Pyrrolidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-alpha-(2-methylpropyl)-2-oxo-,[S-(R,S)]-(9CI) is also utilized in research and development for the exploration of new peptide-based therapeutics and the study of peptide-protein interactions. Its potential applications in this field could lead to the discovery of new drugs and治疗方法 (治疗方法) for various diseases and conditions.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Relevant articles and documents

Cyclic peptides as selective tachykinin antagonists

Twenty homodetic cyclic peptides based on the C-terminal sequence of substance P were prepared (Table I) by a combination of solid-phase techniques and cyclizations using azide coupling procedures. Incorporation of dipeptide mimics based on substituted γ-