148870-57-9

Basic information

• Product Name: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
• Synonyms: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one;3-(3-Iodopropyl)-7,8-diMethoxy-1,3-dihydro-2H-3-benzazepin-2-one;7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on;1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one;3-(3-iodopropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one;7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H;3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;Ivabradine Impurity g
• CAS NO: 148870-57-9
• Molecular Formula: C₁₅H₁₈INO₃
• Molecular Weight: 387.21279
• EINECS: 1806241-263-5
• Mol File: 148870-57-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 504.51 °C at 760 mmHg
• Flash Point: 258.919 °C
• Appearance: /
• Density: 1.513
• Vapor Pressure: 2.64E-10mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.23±0.20(Predicted)
• CAS DataBase Reference: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one(148870-57-9)
• EPA Substance Registry System: 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one(148870-57-9)

Safety Data

• Hazardous Substances Data: 148870-57-9(Hazardous Substances Data)

Usage

General Description

7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one is a chemical compound that consists of a benzazepine ring structure with two methoxy and one iodopropyl group attached to it. It belongs to the class of organic compounds known as flavonoids. 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one is not naturally occurring but has potential applications in medicinal chemistry and drug development due to its unique structure and properties. It may also have potential uses in research and experimental studies related to neurotransmitters and neuropharmacology. Further studies and research are needed to explore the full spectrum of its potential uses and applications.

InChI:InChI=1/C15H18INO3/c1-19-13-8-11-4-7-17(6-3-5-16)15(18)10-12(11)9-14(13)20-2/h4,7-9H,3,5-6,10H2,1-2H3

Upstream product

• 85175-59-3 3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one 
• 73954-34-4 N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 5663-56-9 2-(3,4-dimethoxyphenyl)acetamide 
• 73942-87-7 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 

Downstream Products

• 155974-00-8 ivabradine 
• 1086026-31-4 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 
• 96254-90-9 3-(3-{Allyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 
• 85175-76-4 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.

PROCESS FOR PREPARATION OF IVABRADINE

A process for the preparation of ivabradine pharmaceutically acceptable salts is disclosed. An amorphous form of ivabradine hydrochloride and a process for the preparation of it are also provided.

PROCESS FOR PREPARATION OF IVABRADINE

The present invention describes a new process for optical resolution of [N-[[3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine] which is an intermediate in the preparation of ivabradine.