15891-50-6

Basic information

• Product Name: AC-NVA-OH
• Synonyms: AC-NVA-OH;ACETYL-L-NORVALINE;ACETYL-L-2-AMINOVALERIC ACID;Acrtyl-L-Norvaline;N-Acetyl-L-Norvaline;Ac-Nva-OH(N-Acetyl-L-Norvaline);(2S)-2-(Acetylamino)pentanoic acid;(S)-2-(Acetylamino)pentanoic acid
• CAS NO: 15891-50-6
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• Mol File: 15891-50-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 371.8oC at 760 mmHg
• Flash Point: 178.7oC
• Appearance: /
• Density: 1.097±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: AC-NVA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-NVA-OH(15891-50-6)
• EPA Substance Registry System: AC-NVA-OH(15891-50-6)

Safety Data

• Hazardous Substances Data: 15891-50-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C7H13NO3/c1-3-4-6(7(10)11)8-5(2)9/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1

Upstream product

• 692-33-1 N-allylacetamide 
• 60-35-5 acetamide 
• 123-72-8 butyraldehyde 
• 106-88-7 ethyloxirane 
• 201230-82-2 carbon monoxide 
• 760-78-1 2-aminopentanoic acid 
• 108-24-7 acetic anhydride 
• 1896-62-4 (E)-benzalacetone 
• 187737-37-7 propene 
• 627-27-0 homoalylic alcohol 
• 504-61-0 (E)-but-2-enol 
• 82518-89-6 acetylamino-propyl-malonic acid diethyl ester 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 6600-40-4 L-Norvaline 

Downstream Products

• 2013-12-9 D-norvaline 
• 6600-40-4 L-Norvaline 
• 57357-56-9 N-acetyl-D-norvaline 
• 399035-16-6 N-[1-(4-methyl-benzoyl)-butyl]-acetamide 
• 6600-40-4 L-norvaline 
• 498-18-0 D-norvaline 
• 1188-37-0 N-acetyl-(S)-glutamic acid 
• 1242985-35-8 (R)-4-((R)-3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-37-0 (R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-41-6 (R)-4-((R)-3-oxo-1,3-diphenylpropyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-40-5 (R)-4-((S)-1-(furan-2-yl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1575837-19-2 (3R,4R)-3-benzamido-2,5-dioxo-4-phenyl-3-propylpyrrolidin-1-yl acetate 

Relevant articles and documents

Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres

Hepsin is a type II transmembrane serine protease (TTSP) associated with cell proliferation and overexpressed in several types of cancer including prostate cancer (PCa). Because of its significant role in cancer progression and metastasis, hepsin is an attractive protein as a potential therapeutic and diagnostic biomarker for PCa. Based on the reported Leu-Arg dipeptide-based hepsin inhibitors, we performed structural modification and determined in vitro hepsin- and matriptase-inhibitory activities. Comprehensive structure-activity relationship studies identified that the p-guanidinophenylalanine-based dipeptide analog 22a exhibited a strong hepsin-inhibitory activity (Ki = 50.5 nM) and 22-fold hepsin selectivity over matriptase. Compound 22a could be a prototype molecule for structural optimization of dipeptide-based hepsin inhibitors.

Catalytic asymmetric synthesis of functionalized α,α- disubstituted α-amino acid derivatives from racemic unprotected α-amino acids via in-situ generated azlactones

Masked and activated highly enantioenriched α,α-disubstituted α-amino acids with an additional adjacent stereocenter were formed by a tandem reaction involving five steps using racemic unprotected amino acid substrates. Key step is the 1,4-addition of in-situ generated azlactones to a broad number of enones. The products of this step-economic route can, e.g., be useful for a divergent and rapid access to biologically interesting unnatural glutamic acid derivatives. Copyright

Palladium-catalyzed amidocarbonylation improved by recyclable ionic liquids

Two types of ionic liquids (halide anion ionic liquids and Brensted acidic ionic liquids) were first applied to improve the palladium-catalyzed amidocarbonylation. Both the palladium catalyst and the ionic liquids could be recycled at least five times without significant loss in catalytic activity. Georg Thieme Verlag Stuttgart.