187671-16-5

Basic information

• Product Name: Fmoc-Asp-OFm
• Synonyms: Fmoc-Asp-OFm(Fmoc-L-AsparticacidFluorenylmethylester);N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-Asp-OFm;(S)-4-((9H-fluoren-9-yl)methoxy)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-oxobutanoic acid;N-alpha-FMoc-L-aspartic acid-alpha-9-fluorenylMethyl ester;Fmoc-L-Asp-OFm;Fmoc-L-aspartic acid a-9-fluorenylmethyl ester≥ 98% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl Asp-OFm
• CAS NO: 187671-16-5
• Molecular Formula: C33H27NO6
• Molecular Weight: 533.57
• Product Categories: Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 187671-16-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 777.9 °C at 760 mmHg
• Flash Point: 424.3 °C
• Appearance: /
• Density: 1.322
• Refractive Index: 1.647
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: Fmoc-Asp-OFm(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Asp-OFm(187671-16-5)
• EPA Substance Registry System: Fmoc-Asp-OFm(187671-16-5)

Safety Data

• Hazardous Substances Data: 187671-16-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C33H27NO6/c35-31(36)17-30(32(37)39-18-28-24-13-5-1-9-20(24)21-10-2-6-14-25(21)28)34-33(38)40-19-29-26-15-7-3-11-22(26)23-12-4-8-16-27(23)29/h1-16,28-30H,17-19H2,(H,34,38)(H,35,36)/t30-/m0/s1

Upstream product

• 24324-17-2 9-Fluorenylmethanol 
• 71989-14-5 Fmoc-(tBu)Asp-OH 

Downstream Products

• 35309-53-6 (3S,6S)-2,5-dioxopiperazine-3,6-diacetic acid 

Relevant articles and documents

Synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid

The invention discloses a synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid, which comprises the following steps: by taking Fmoc-Asp (OtBu)-OH or Fmoc-Glu (OtBu)-OH as a raw material, reacting with 9-fluorene methanol to obtain fluorene methyl ester of fully protected amino acid, and then removing side chain tert-butoxy to obtain protected amino acid Fmoc-Asp-OFm or Fmoc-Glu-OFm; 2-CTC Resin resin is used as a carrier to be bonded with Fmoc-Asp-OFm or Fmoc-Glu-OFm side chain gamma-carboxyl, solid-phase cyclization is carried out to synthesize full-protection cyclic dipeptide, and the cyclic dipeptide with aspartic acid or glutamic acid at the carbon end is obtained through cutting and cracking. According to the method, 9-fluorene methanol is introduced to protect carboxyl, the carboxyl can be smoothly removed in the solid-phase synthesis process of the dipeptide, the whole process is easy to operate, the solid-phase cyclization efficiency is high, the purity is high, and the method can be suitable for batch synthesis of cyclic dipeptide with aspartic acid or glutamic acid at the carbon end.