205445-51-8 Usage
Description
BOC-D-3,4-Difluorophe, also known as Boc-D-3,4-difluorophenylalanine, is a synthetic amino acid derivative featuring a 3,4-difluorophenyl group attached to the α-carbon of the D-phenylalanine. It is characterized by its white to light yellow crystal powder appearance and is commonly used in the synthesis of various bioactive compounds.
Uses
Used in Pharmaceutical Industry:
BOC-D-3,4-Difluorophe is used as a key intermediate in the discovery and synthesis of pyrrolopyrimidine inhibitors of Akt, which are potential antitumor agents. These inhibitors target the Akt protein, a serine/threonine kinase involved in cell survival, growth, and angiogenesis, and are being explored for their potential in treating various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 205445-51-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,4,4 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 205445-51:
(8*2)+(7*0)+(6*5)+(5*4)+(4*4)+(3*5)+(2*5)+(1*1)=108
108 % 10 = 8
So 205445-51-8 is a valid CAS Registry Number.
205445-51-8Relevant articles and documents
Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.
scheme or table, p. 5607 - 5612 (2010/11/17)
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.