249648-08-6

Basic information

• Product Name: 3,4-Difluoro-D-phenylalanine
• Synonyms: (R)-2-AMino-3-(3,4-difluorophenyl)propanoic acid;D-3,4-Difluorophenylalanine≥ 99% (Assay);D-Phe(3,4-DiF)-OH
• CAS NO: 249648-08-6
• Molecular Formula: C9H9F2NO2
• Molecular Weight: 201.17
• Product Categories: Amino Acids
• Mol File: 249648-08-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 311.9 °C at 760 mmHg
• Flash Point: 142.5 °C
• Appearance: /
• Density: 1.379
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Store at 0-5°C
• PKA: 2.16±0.20(Predicted)
• CAS DataBase Reference: 3,4-Difluoro-D-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluoro-D-phenylalanine(249648-08-6)
• EPA Substance Registry System: 3,4-Difluoro-D-phenylalanine(249648-08-6)

Safety Data

• Hazardous Substances Data: 249648-08-6(Hazardous Substances Data)

Usage

Chemical Properties

Almost white powder

InChI:InChI=1/C9H9F2NO2/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8H,4,12H2,(H,13,14)/t8-/m1/s1

Upstream product

• 152152-17-5 3-(3,4-difluorophenyl)-2-propenoic acid 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 
• 2927-34-6 3,4-difluorotoluene 
• 15017-45-5 2-Acetylamino-2-(3,4-difluorobenzyl)malonic acid diethyl ester 
• 266360-51-4 2-acetylamino-3-(3,4-difluoro-phenyl)-propionic acid 
• 266360-57-0 N-Acetyl-3,4-difluoro-D-phenylalanine 

Downstream Products

• 198474-90-7 (S)-2-((tert-butoxycarbonyl)amino)-3-(3,4-difluorophenyl)propanoic acid 

Relevant articles and documents

ANTIBACTERIALS AND/OR MODULATORS OF BIOFILM FORMATION AND METHODS OF USING THE SAME

Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.

Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L-1 d-1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.

Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase.

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