26582-86-5Relevant articles and documents
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
Bond, Andrew D.,Hanby, Abigail R.,King, Thomas A.,Moss, Thomas A.,Sore, Hannah F.,Spring, David R.,Stewart, Hannah L.
, p. 6818 - 6821 (2020/07/04)
Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.
Synthesis and antitumoral evaluation of benzyl (1S)-2-[2-(monosubstituted- benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate
Montenegro, Raquel Carvalho,Lotufo, Leticia Veras Costa,De Moraes, Manoel Odorico,Pessoa, Claudia Do O.,Rodrigues, Felipe Augusto Rocha,Pinheiro, Alessandra Campbell,Nogueira, Thais Cristina Mendonca,De Souza, Marcus Vinicius Nora
, p. 257 - 262 (2012/06/18)
A series of 14 N-acyl-hydrazones L-serine derivatives have been synthesized and evaluated for their in vitro antitumoral activities against four neoplastic cancer cells: HL-60 (leukemia), MDA-MB-435 (melanoma), HCT-8 (colon) and SF-295 (nervous system). F
