26763-19-9

Basic information

• Product Name: POLYADENYLIC ACID (5') POTASSIUM SALT
• Synonyms: POLY RA POTASSIUM SALT;POLYADENYLIC ACID POTASSIUM SALT;POLY(A);POLY-ADENYLIC ACID;POLYADENYLIC ACID (5') POTASSIUM SALT;POLY[A] POTASSIUM SALT;polyadenylic acid (5');POLYADENYLIC ACID (5'), POTASSIUM
• CAS NO: 26763-19-9
• Molecular Formula: C10H13KN5O7P
• Molecular Weight: 385.311581
• Product Categories: Biomaterials;Materials Science;Oligonucleotide Polymers and Copolymers;Biochemicals and Reagents;Nucleosides;Nucleotides;Oligonucleotides;Synthetic Oligonucleotides and Related Reagents
• Mol File: 26763-19-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: POLYADENYLIC ACID (5') POTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: POLYADENYLIC ACID (5') POTASSIUM SALT(26763-19-9)
• EPA Substance Registry System: POLYADENYLIC ACID (5') POTASSIUM SALT(26763-19-9)

Safety Data

• WGK Germany: 3
• F: 3-10-21
• Hazardous Substances Data: 26763-19-9(Hazardous Substances Data)

Usage

Description

POLYADENYLIC ACID (5') POTASSIUM SALT, also known as Poly(A), is a synthetic analog of the polyadenylic acid found in eukaryotic mRNA. It is a linear polymer of adenylic acid residues linked by phosphodiester bonds and has a high affinity for binding to cationic liposomes and nucleic acids. Poly(A) plays a crucial role in various applications, including drug development, diagnostic assays, and nucleic acid precipitation.

Uses

Used in Drug Development:
POLYADENYLIC ACID (5') POTASSIUM SALT is used as a target for small molecule mRNA in the development of therapeutic agents. It is employed to evaluate the binding of potential therapeutic agents, such as the Isoquinoline group of alkaloids, which can modulate mRNA function and have potential applications in treating various diseases.
Used in Diagnostic Assays:
Poly(A) is used in droplet digital PCR (ddPCR) assay, a highly sensitive and accurate method for detecting and quantifying nucleic acids. It serves as a carrier for the amplification and detection of specific DNA or RNA sequences, enabling precise measurement of target molecules in various biological samples.
Used in Nucleic Acid Precipitation:
POLYADENYLIC ACID (5') POTASSIUM SALT is used as a carrier for the quantitative precipitation of DNA and RNA. It binds to nucleic acids through electrostatic interactions, facilitating their precipitation and separation from other cellular components. This property makes Poly(A) a valuable tool in nucleic acid purification, isolation, and analysis.

Biochem/physiol Actions

Polyadenylic acid (Poly(A)) tails present at 3′ end are produced in the cell nucleus. It contains ~250 nucleotides in mammalian cells.?Poly(A) regulates mRNA decay and the initiation of translation. Cytoplasmic poly(A) extension modulates translation.