35150-07-3 Usage
Description
D-1-N-Boc-prolinamide, also known as 1-Boc-L-prolinamide, is a chemical compound that serves as a reagent in the synthesis of various organic compounds. It is characterized by the presence of a Boc (tert-butyloxycarbonyl) protecting group and a prolinamide moiety, which are crucial for its applications in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
D-1-N-Boc-prolinamide is used as a reagent for the preparation of thiazole amide peptidomimetics. These peptidomimetics are designed to inhibit the activity of apoptosis proteins, which play a crucial role in programmed cell death. By targeting these proteins, D-1-N-Boc-prolinamide contributes to the development of potential therapeutic agents for the treatment of various diseases, including cancer and neurodegenerative disorders.
Used in Organic Synthesis:
In the field of organic synthesis, D-1-N-Boc-prolinamide is utilized as a building block for the synthesis of complex organic molecules. Its Boc protecting group can be selectively removed under mild acidic conditions, allowing for the controlled formation of amide bonds and the assembly of larger molecular structures. This makes D-1-N-Boc-prolinamide a valuable tool for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry Research:
D-1-N-Boc-prolinamide is also employed in medicinal chemistry research for the design and synthesis of novel bioactive compounds. Its unique structural features enable the development of new chemical entities with potential therapeutic applications. Researchers can use D-1-N-Boc-prolinamide to explore the structure-activity relationships of various biologically active molecules, ultimately leading to the discovery of new drugs and drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 35150-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,1,5 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 35150-07:
(7*3)+(6*5)+(5*1)+(4*5)+(3*0)+(2*0)+(1*7)=83
83 % 10 = 3
So 35150-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-5-7(12)8(11)13/h7H,4-6H2,1-3H3,(H2,11,13)/t7-/m0/s1
35150-07-3Relevant articles and documents
Synthetic Studies on Alotamide A: Construction of N-Demethylalotamide A
Domínguez, Marta,Román, David,Souto, José A.,de Lera, ángel R.
supporting information, p. 6057 - 6070 (2021/12/10)
Several approaches to the synthesis of cyclodepsipeptide natural product alotamide A are described, eventually affording a very advanced N-demethylated analogue of the targeted natural product. The difficulties found in our endeavors on the synthesis of alotamide A have allowed us to gather some valuable information regarding the most convenient synthetic step for each key transformation. The intramolecular Csp2?Csp2 Stille cross-coupling and the macrolactam formation were found to be reliable protocols for the final construction of the alotamide A skeleton.
Process Development of a Copper(II)-Catalyzed Dehydration of an N -Acyl Prolinal Oxime: Cascade Process and Application at an Elevated Lab Scale
Nonnhoff, Jannis,Gr?ger, Harald
supporting information, p. 4672 - 4677 (2021/10/07)
Chiral N-acyl amino nitriles are important structural motifs in several pharmaceuticals such as Vildagliptin or Saxagliptin. Cyanidefree access to such nitriles is provided by a copper-catalyzed dehydration of oximes, which are readily available by condensation of chiral aldehydes resulting from the chiral pool with hydroxylamine. The application in a cascade process without the need for intermediate purification as well as a demonstrated scalability show the robustness of this methodology.
Evidence and exploitation of dicationic ammonium-nitrilium superelectrophiles: direct synthesis of unsaturated piperidinones
Cantin, Thomas,Morgenstern, Yvonne,Mingot, Agnès,Kornath, Andreas,Thibaudeau, Sébastien
supporting information, p. 11110 - 11113 (2020/10/05)
Exploiting superacid activation, the reactivity of aminonitriles was enhanced through the transient formation of highly reactive ammonium-nitrilium superelectrophiles. Demonstrated by usingin situlow-temperature NMR experiments and confirmed by X-ray diffraction analysis, these dications can be intramolecularly trapped by non-activated alkenes to generate unsaturated piperidinones, including enantioenriched ones, in a straightforward way.
