49823-14-5

Basic information

• Product Name: 1-(2-Phenylethyl)-1H-imidazole
• Synonyms: 1-(2-Phenylethyl)-1H-imidazole;1-Phenethylimidazole;1-phenethyl-1H-imidazole;1H-Imidazole,1-(2-phenylethyl)-;1-Phenethylimidazole/1-(2-Phenylethyl)-1H-imidazole
• CAS NO: 49823-14-5
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• EINECS: 1308068-626-2
• Mol File: 49823-14-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 32.0 to 36.0 °C
• Boiling Point: 145°C/0.2mmHg(lit.)
• Flash Point: 164.958 °C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 7.04±0.10(Predicted)
• CAS DataBase Reference: 1-(2-Phenylethyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Phenylethyl)-1H-imidazole(49823-14-5)
• EPA Substance Registry System: 1-(2-Phenylethyl)-1H-imidazole(49823-14-5)

Safety Data

• Hazardous Substances Data: 49823-14-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow oily solid or liquid

Uses

1-Phenethylimidazole, is a N-substituted imidazole derivative, which has been shown to act as an inhibitor of nitric oxide synthase.

InChI:InChI=1/C11H12N2/c1-2-4-11(5-3-1)6-8-13-9-7-12-10-13/h1-5,7,9-10H,6,8H2

Upstream product

• 288-32-4 1H-imidazole 
• 4455-09-8 2-phenylethyl tosylate 
• 103-63-9 1-phenyl-2-bromoethane 
• 622-24-2 2-phenylethyl chloride 
• 876926-01-1 2-bromo-1-(2-phenylethyl)-1H-imidazole 
• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 64-04-0 phenethylamine 
• 60-12-8 2-phenylethanol 

Downstream Products

• 142654-77-1 1-acetyl-4-[[1-(2-phenylethyl)-1H-imidazol-2yl]carbonyl]piperidine 
• 1176202-59-7 1,3-di(2-phenylethyl)imidazolium bromide 

Relevant articles and documents

Novel phenethylimidazolium based ionic liquids: Design, microwave synthesis, in-silico, modeling and biological evaluation studies

An eco-friendly preparation method for the novel bioactive imidazolium ionic liquids halides (ILs) was developed under microwave-assisted conditions. Synthesized ILs were characterized by spectroscopic techniques. Selected ILs were investigated for their antimicrobial activity against highly resistant Gram-positive and Gram-negative bacterial strains. Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-iumchloride (4) showed high antimicrobial activity against the Staphylococcus aureus strain in the inhibition zone tests and displayed low MIC and MBC levels against almost all tested bacteria. Furthermore, the ILs were screened in vitro against human hepatocellular carcinoma (HepG-2), human breast adenocarcinoma (MCF-7), and human colon carcinoma (Caco-2) cell lines. The screening results showed excellent to moderate anticancer activity across the ILs. Among the synthesized ILs, Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-ium chloride (4) and 1-phenethyl-3-(3-phenoxypropyl)-1H-imidazol-3-ium bromide (7) were found to exhibit the most promising ant proliferative effects and had the lowest IC50 values. The docking study suggested strong interaction of ILs with DNA with binding energy ranging from ?4.9 to ?4.1 kcal/mol. ILs 4 and 7 were most strongly bonded with ?4.9 and ?4.8 kcal/mol binding energy; confirming in vitro anticancer results.

A PROCESS FOR THE PREPARATION OF ALCAFTADINE

An improved process for preparation of Alcaftadine, its crystalline form or its pharmaceutically acceptable salts is disclosed alongwith a process for purification of Alcaftadine or its pharmaceutically acceptable salts.

Substituted heteroaromatic compounds: Effect on nicotine self-administration in rats

Rationale: Certain compounds that nonselectively inhibit a prominent human nicotine-metabolizing enzyme (i.e., human cytochrome P-450 2A6, hCYP 2A6) showed inhibition of smoking in humans. However, a comprehensive examination of hCYP 2A6 inhibitors to dec