54008-77-4

Basic information

• Product Name: 2-BROMO-1-BENZOFURAN
• Synonyms: 2-BROMO-1-BENZOFURAN;2-BROMOBENZOFURAN;2-Bromo-1-benzofurane;2-Bromo-1-benzofuran, 90+%;2-Bromobenzo[b]furan;Benzofuran, 2-broMo-;2-Bromobenzo[b]furan 90%;2-Bromo-1-benzofuran:2-bromobenzofuran
• CAS NO: 54008-77-4
• Molecular Formula: C₈H₅BrO
• Molecular Weight: 197.03
• Mol File: 54008-77-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 247-247.5 °C
• Boiling Point: 234℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.608
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-BROMO-1-BENZOFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-BENZOFURAN(54008-77-4)
• EPA Substance Registry System: 2-BROMO-1-BENZOFURAN(54008-77-4)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 54008-77-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-benzofuran is a chemical compound with the molecular formula C8H5BrO. It is a benzofuran derivative with a bromine atom attached to the 2-position of the benzofuran ring. 2-BROMO-1-BENZOFURAN is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and reactivity make it a useful reagent in organic chemistry for the formation of carbon-carbon and carbon-heteroatom bonds. It is also used in the development of new materials and as a precursor for the production of agrochemicals. However, it is important to handle this compound with care as it is potentially hazardous and should only be used by trained professionals in a controlled laboratory environment.

InChI:InChI=1/C8H5BrO/c9-8-5-6-3-1-2-4-7(6)10-8/h1-5H

Upstream product

• 91703-34-3 2-(β,β-dibromovinyl)phenol 
• 1378942-55-2 2-(gem-dibromovinyl)phenol-d 
• 603-33-8 triphenylbismuthane 
• 90-02-8 salicylaldehyde 
• 98437-24-2 benzofuran-2-boronic acid 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 496-41-3 Benzofuran-2-carboxylic acid 

Downstream Products

• 496-41-3 Benzofuran-2-carboxylic acid 
• 36724-16-0 2-(methylsulfanyl)benzofuran 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 4265-27-4 2-n-butylbenzo[b]furan 
• 77234-10-7 2-(2phenylethynyl)benzo[b]furan 
• 1839-72-1 2-phenylbenzofuran 
• 13524-66-8 2-benzyldihydrobenzofuran 
• 4265-14-9 2-benzylbenzofuran 
• 26870-34-8 2-(3’-methoxyphenyl)benzofuran 
• 6161-50-8 3,3'-dimethoxybiphenyl 
• 69976-38-1 2-(4-fluorophenyl)benzofuran 
• 398-23-2 4,4'-difluorobiphenyl 
• 92-52-4 biphenyl 
• 25664-48-6 2-p-tolyl-benzofuran 

Relevant articles and documents

Palladium-Catalyzed Tandem Synthesis of 2-Trifluoromethylthio(seleno)-Substituted Benzofused Heterocycles

The tandem synthesis of 2-trifluoromethylthio(seleno)-substituted benzofurans using palladium-catalyzed conditions is reported. Trifluoromethylthio(seleno)lation of 2-(2,2-dibromovinyl)phenols with (bpy)CuSCF3 or [(bpy)CuSeCF3]2

Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents

A highly efficient and simple route for the synthesis of 2-substituted benzo[ b ]furans has been developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b ]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl-substituted benzo[ b ]furan derivatives can be obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls bearing electron-donating or electron-withdrawing groups in 2-halobenzo[ b ]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b ]furans as well, and three bioactive molecules with 2-substituted benzo[ b ]furan skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale make this protocol a potentially practical method to synthesize 2-substituted benzo[ b ]furan derivatives. On the basis of the experimental results, a possible catalytic cycle has been proposed.

Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C-O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.