59760-01-9

Basic information

• Product Name: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER
• Synonyms: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER;(S)-(-)-2-oxo-1,5-imidazolidine-dicarboxylic acid;(S)-2-OXO-IMIDAZOLIDINE-1,5-DICARBOXYLIC ACID 1-BENZYL ESTER;2-oxo-1,5-imidazolidinedicarboxylic acid, 1-benzyl ester;(4S)-3-[(Benzyloxy)carbonyl]-2-oxoimidazolidine-4-carboxylic acid;(S)-3-CBZ-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID;(S)-()-1-Cbz-2-Oxo-5-iMidazolidinecarboxylic acid;(S)-(-)-1-Z-2-Oxo-5-iMidazolidinecarboxylic acid
• CAS NO: 59760-01-9
• Molecular Formula: C₁₂H₁₂N₂O₅
• Molecular Weight: 264.23
• Product Categories: Chiral Building Blocks;Heterocyclic Building Blocks;Imidazolines/Imidazolidines
• Mol File: 59760-01-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 189 °C (dec.)(lit.)
• Appearance: /
• Density: 1.444g/cm3
• Refractive Index: 1.598
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.22±0.20(Predicted)
• CAS DataBase Reference: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER(59760-01-9)
• EPA Substance Registry System: (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER(59760-01-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 59760-01-9(Hazardous Substances Data)

Usage

Uses

Z-protected imidazolidinone for sequential N-alkylation.

InChI:InChI=1/C12H12N2O5/c15-10(16)9-6-13-11(17)14(9)12(18)19-7-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,17)(H,15,16)/t9-/m0/s1

Upstream product

• 4474-86-6 (R)-4-amino-2-(((benzyloxy)carbonyl)amino)-4-oxobutanoic acid 
• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 

Downstream Products

• 89384-29-2 benzyl (4S)-3-(benzyloxycarbonyl)-2-oxoimidazolidine-4-carboxylate 
• 77999-24-7 (S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester 
• 865535-05-3 (1'R,2'S,5'R)-menthyl 3-benzyloxycarbonyl-2-oxaimidazolidine-4(S)-carboxylate 
• 845543-46-6 (S)-1-benzyl 4-tert-butyl 3-methyl-2-oxoimidazolidine-1,4-dicarboxylate 
• 98649-15-1 1‐benzyl 4‐methyl 3‐methyl‐2‐oxoimidazolidine‐1,4‐dicarboxylate 
• 90157-23-6 benzyl (S)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidine-1-carboxylate 
• 393548-36-2 (S)-dibenzyl 3-(2-ethoxy-2-oxoethyl)-2-oxoimidazolidine-1,5-dicarboxylate 
• 1448348-16-0 (S)-3,4-dibenzyl 1-tert-butyl 2-oxoimidazolidine-1,3,4-tricarboxylate 
• 1134289-61-4 (S)-5-dimethylcarbamoyl-2-oxo-imidazolidine-1-carboxylic acid benzyl ester 
• 1065144-47-9 (S)-5-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-2-oxo-imidazolidine-1-carboxylic acid benzyl ester 
• 117560-17-5 (S)-3-[(S)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester 
• 117560-18-6 (S)-3-[(S)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester; compound with (Z)-but-2-enedioic acid 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

The application relates to heterocyclic amide derivatives and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation. (Formula (I))

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.