67579-81-1 Usage
Description
TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE, also known as Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine, is a valuable research chemical utilized in various organic synthesis and chemical processes. It is characterized by its unique structure and reactivity, making it a versatile compound in the field of chemistry.
Uses
Used in Catalysts for N-Amidation and N-Arylation:
TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE is used as a catalyst component in the N-amidation of aryl and heteroaryl iodides, bromides, and sometimes unactivated aryl chlorides, in conjunction with CuI. This catalyst system is known for its generality and high efficiency, facilitating the formation of amide bonds in organic synthesis.
Additionally, TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE is used for the N-arylation of indoles, further expanding its applications in organic chemistry.
Used in Ligand for Copper-Catalyzed C-N Coupling Reactions:
TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE serves as a ligand in copper-catalyzed C-N coupling reactions, enabling the synthesis of various products such as:
1. Vinylsulfoximines: Obtained from NH sulfoximes and vinyl bromides, these compounds find applications in the pharmaceutical industry and as intermediates in the synthesis of complex molecules.
2. N-Arylpyridones: Produced via the reaction between 2-substituted pyridines and aryl halides, these compounds are valuable in the development of pharmaceuticals and agrochemicals.
3. N-Aryl amines: Derived from the reaction between amines and aryl iodides/aryl bromides, N-aryl amines are important building blocks in the synthesis of various organic compounds, including pharmaceuticals and dyes.
Check Digit Verification of cas no
The CAS Registry Mumber 67579-81-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,5,7 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67579-81:
(7*6)+(6*7)+(5*5)+(4*7)+(3*9)+(2*8)+(1*1)=181
181 % 10 = 1
So 67579-81-1 is a valid CAS Registry Number.
67579-81-1Relevant articles and documents
Method for synthesizing trans-cyclohexanedimethanamine
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Paragraph 0011; 0012; 0013; 0014; 0015; 0016; 0017; 0018, (2017/08/28)
The invention discloses a method for synthesizing trans-cyclohexanedimethanamine, comprising steps of reacting cyclohexene oxide and methylamine aqueous solution under the catalysis of boric acid, and then adding sulfuric acid, dewatering to form an ester, ring-closing under alkaline conditions, adding methylamine aqueous solution and boric acid for hermetic reaction, and distilling to obtain trans-cyclohexanedimethanamine. The synthetic process is simple to perform, provides facilitated isolation and purification and high yield and product purity, and is suitable for batch production.
Method for catalytic preparation of hydromorphone and hydrocodone
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Page/Page column 7-8, (2008/12/06)
The present invention generally relates to catalysts of formula (III) [in-line-formulae][M(P(Ra)(Rb)N(Rc)(Rd))2Xn]mYp [/in-line-formulae]that selectively convert morphine/codeine to hydromorphone/hydrocodone, and methods of use thereof.
The role of chelating diamine ligands in the Goldberg reaction: A kinetic study on the copper-catalyzed amidation of aryl iodides
Strieter, Eric R.,Blackmond, Donna G.,Buchwald, Stephen L.
, p. 4120 - 4121 (2007/10/03)
The mechanistic details of the Cu-catalyzed amidation of aryl iodides are presented. The kinetic data suggest that the diamine ligand prevents multiple ligation of the amide. The formation of an amidocuprate species external to the catalytic cycle helped to rationalize the dependence on diamine concentration and the inverse dependence on amide concentration at low diamine concentrations. The intermediacy of a Cu(I) amidate was established through both its chemical and kinetic competency. Copyright
