74592-33-9Relevant articles and documents
Synthesis method of 1-aminomethyl-1-cyclopropanol
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Paragraph 0044-0052, (2020/08/09)
The invention discloses a synthetic method of 1-aminomethyl-1-cyclopropanol. The synthetic method comprises the following steps: adding a compound C00 into an aqueous potassium carbonate solution to form a first solution; adding an aqueous solution of C01 into the first solution for a reaction; combining organic phases, carrying out cleaning with saline water, and performing drying, filtering andconcentrating to obtain a compound C02; dissolving the compound C02 in tetrahydrofuran to form a second solution; adding tetraisopropyl titanate into the second solution to form a third solution; adding an ethyl magnesium bromide solution into the third solution for a reaction; adding an aqueous ammonium chloride solution into the solution for a quenching reaction; combining organic layers to obtain a compound C03; dissolving the compound C03 into an absolute ethyl alcohol solution to form a fourth solution; adding a sodium hydroxide solution into the fourth solution; adding a hydroxylamine hydrochloride solution into the fourth solution to form a fifth solution; and adding a sodium hydroxide solution into the fifth solution until the pH value is 6-7, and carrying out distilling to removea water phase, thereby obtaining the product, i.e., 1-aminomethyl-1-cyclopropanol. In this way, palladium hydroxide is not used as a catalyst, and synthesis cost is reduced.
A convenient procedure for preparation of 1-(1-aminoalkyl)-1-cyclopropanols from N-benzyl α-amino acid esters
Lysenko,Kulinkovich
, p. 1238 - 1243 (2007/10/03)
The reaction of N-benzyl α-amino acid ethyl esters with ethylmagnesium bromide in the presence of a catalytic amount of titanium tetraisopropoxide leads to formation of the corresponding 1-aminoalkyl-1-cyclopropanols in high yields. Hydrogenation of the l
