77385-90-1

Basic information

• Product Name: N,N-DIBENZYLGLYCINE ETHYL ESTER
• Synonyms: N,N-DIBENZYLGLYCINE ETHYL ESTER;Di-Bzl-Gly-OEt;DIBENZYLAMINO-ACETIC ACID ETHYL ESTER;N,N-dibenzylglycine ethyl este;Ethyl (dibenzylamino)acetate;Ethyl N,N-dibenzylglycinate;N,N-Dibenzyl-O-ethylglycinate;N,N-bis(phenylmethyl)Glycineethyl ester
• CAS NO: 77385-90-1
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.36484
• Product Categories: Amino Acid Ethyl Esters;Amino Acids;Amino Acids (C-Protected);Biochemistry
• Mol File: 77385-90-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 376℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.091
• Vapor Pressure: 7.59E-06mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 5.47±0.50(Predicted)
• CAS DataBase Reference: N,N-DIBENZYLGLYCINE ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIBENZYLGLYCINE ETHYL ESTER(77385-90-1)
• EPA Substance Registry System: N,N-DIBENZYLGLYCINE ETHYL ESTER(77385-90-1)

Safety Data

• Hazardous Substances Data: 77385-90-1(Hazardous Substances Data)

Usage

Chemical Properties

White to almost white crystalline powder

InChI:InChI=1/C18H21NO2/c1-2-21-18(20)15-19(13-16-9-5-3-6-10-16)14-17-11-7-4-8-12-17/h3-12H,2,13-15H2,1H3

Upstream product

• 24824-93-9 chloromethyl p-tolyl sulfoxide 
• 541-41-3 chloroformic acid ethyl ester 
• 103-49-1 dibenzylamine 
• 64-17-5 ethanol 
• 17360-47-3 N,N-dibenzylglycine 
• 109-92-2 ethyl vinyl ether 
• 100-44-7 benzyl chloride 
• 459-73-4 GlyOEt*HCl 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 125261-03-2 2-Dibenzylamino-3-hydroxy-4-(2-methyl-[1,3]dioxolan-2-yl)-butyric acid ethyl ester 
• 134936-18-8 (R/S)-N,N-dibenzylthreonine ethyl ester and (R/S)-N,N-dibenzyl-allo-threonine ethyl ester 
• 106501-85-3 trans-1-methyl-3-(N,N-dibenzylamino)-4-phenyl-β-azetidinone 
• 106501-85-3 cis-1-methyl-3-(N,N-dibenzylamino)-4-phenyl-β-azetidinone 
• 428855-17-8 1-((diphenylmethylamino)methyl)cyclopropan-1-ol 
• 134936-23-5 ethyl (R/S)-2-(dibenzylamino)-3,3-diethoxypropionate 
• 213316-32-6 rac-(1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1219366-56-9 C₂₉H₃₄N₂O₃S 
• 847033-99-2 (-)-ethyl (2S,3R)-2-(dibenzylamino)-3-[(R)-p-toluenesulfinylamino]pent-4-enoate 
• 1439368-35-0 ethyl (2RS)-2-(dibenzylamino)-4-methyl-3-oxopentanoate 

Relevant articles and documents

Biosynthesis of berninamycin: Incorporation of 13C-labeled amino acids

Two-dimensional NMR and FABMS/MS studies agree with the structure for berninamycin A proposed by Abe et al. (Tetrahedron Lett. 1988, 29, 1401-1404). Biosynthetic studies with 13C-enriched amino acids confirm our earlier results that the dehydro

Alpha-substituted-alpha-amino acid ester compound and preparation method thereof

The invention discloses an alpha-substituted-alpha-amino acid ester compound and a preparation method thereof. Aromatic amine and alkenyl ether are added into a reactor and dissolved in a solvent, a reaction is carried out under the action of a palladium catalyst, a ligand and an oxidizing agent, separation and purification are carried out, the alpha-substituted-alpha-amino acid ester compound is obtained, and the reaction formula of the preparation method is shown in the formula (I). According to the method, alkenyl ether and aromatic amine which are simple and easy to obtain are used as reaction raw materials to synthesize a series of alpha-substituted-alpha-amino-acid ester compounds, and the method has the advantages that the raw materials are simple and easy to obtain, operation is convenient, conditions are mild, step atom economy is high, substrate applicability is wide, and functional group tolerance is good.

Intermediate compound of medicine LB80380 and preparing method and application thereof

The invention provides an LB80380 intermediate compound (as shown in formula I in the specification). In the LB80380 intermediate compound, R1, R2, R3 and R4 are chosen from linear chain or branched chain alkyl group, benzyl group which is replaced by one or five R5, or R5CO independently, wherein the R1, the R1, the R3 and the R4 are identical or different; R5 is chosen from hydrogen, C1-C4 alkoxy which is replaced or not replaced, C3-C7 alkenyl alkoxy, or benzyloxy- which is replaced or not replaced. The invention also provides a preparing method and an application of the compound in the formula I. When the compound in formula I is used for preparing a compound (specific chemical formula is in the specification), reaction route raw materials and intermediate materials are low in price and easy to get, cost is low, safety is good, and thus the LB80380 intermediate compound in formula I is applicable to industrial production.