81363-76-0

Basic information

• Product Name: Isopropylsulfonamide
• Synonyms: propane-2-sulfonamide;Isopropylsulfonamide;IsopropylsulfonamidePropane-2-sulfonamide;Propane-2-sulphonamide, 2-Sulphamoylpropane;2-Propanesulfonamide
• CAS NO: 81363-76-0
• Molecular Formula: C₃H₉NO₂S
• Molecular Weight: 123.17
• Product Categories: CHIRAL CHEMICALS
• Mol File: 81363-76-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 61-65 °C(Solv: chloroform (67-66-3); carbon tetrachloride (56-23-5))
• Boiling Point: 216.5 °C at 760 mmHg
• Flash Point: 84.7 °C
• Appearance: /
• Density: 1.194 g/cm³
• Vapor Pressure: 0.14mmHg at 25°C
• Refractive Index: 1.461
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.69±0.60(Predicted)
• CAS DataBase Reference: Isopropylsulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropylsulfonamide(81363-76-0)
• EPA Substance Registry System: Isopropylsulfonamide(81363-76-0)

Safety Data

• Hazardous Substances Data: 81363-76-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H9NO2S/c1-3(2)7(4,5)6/h3H,1-2H3,(H2,4,5,6)

Upstream product

• 10147-37-2 Isopropylsulfonyl chloride 
• 149220-47-3 C₇H₁₇NO₂S 
• 7664-41-7 ammonia 
• 19955-41-0 isopropanesulfinamide 
• 807329-97-1 TurboGrignard 
• 27719-14-8 ethylidene isopropylamine 
• 256532-43-1 N-(tert-butoxycarbonyl) isopropylsulfonamide 
• 149944-33-2 N-benzyl-propane-2-sulfonamide 

Downstream Products

• 126502-39-4 N-{1-(3-Cyano-benzyl)-3-[2-methoxy-4-(propane-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-5-yl}-2-cyclopentyl-acetamide 
• 104448-66-0 2-Ethyl-hexanoic acid {1-[2-methoxy-4-(propane-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-6-yl}-amide 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 354-87-0 pentafluoroethanesulfonyl fluoride 
• 423-40-5 1-perfluoropropanesulfonyl fluoride 
• 14856-91-8 perfluoroisopropylsulfonyl fluoride 
• 1026682-12-1 propane-2-sulfonic acid (7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-phenylsulfanyl-butyl]-cyclopentyl}-heptanoyl)-amide 
• 145878-41-7 1-(Isopropylsulfonylaminocarbonyl)-3-nitro-benzene 
• 1059701-53-9 (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide 
• 945686-05-5 methyl 13-cyclohexyl-10-((isopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylate 
• 1059700-13-8 (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide 
• 1127236-94-5 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1127237-56-2 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methylethyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 14159-48-9 2-propanesulfonic acid 

Relevant articles and documents

Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL

While the biochemistry of rhomboid proteases has been extensively studied since their discovery two decades ago, efforts to define the physiological roles of these enzymes are ongoing and would benefit from chemical probes that can be used to manipulate the functions of these proteins in their native settings. Here, we describe the use of activity-based protein profiling (ABPP) technology to conduct a targeted screen for small-molecule inhibitors of the mitochondrial rhomboid protease PARL, which plays a critical role in regulating mitophagy and cell death. We synthesized a series of succinimide-containing sulfonyl esters and sulfonamides and discovered that these compounds serve as inhibitors of PARL with the most potent sulfonamides having submicromolar affinity for the enzyme. A counterscreen against the bacterial rhomboid protease GlpG demonstrates that several of these compounds display selectivity for PARL over GlpG by as much as two orders of magnitude. Both the sulfonyl ester and sulfonamide scaffolds exhibit reversible binding and are able to engage PARL in mammalian cells. Collectively, our findings provide encouraging precedent for the development of PARL-selective inhibitors and establish N-[(arylsulfonyl)oxy]succinimides and N-arylsulfonylsuccinimides as new molecular scaffolds for inhibiting members of the rhomboid protease family.

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

BENZIMIDAZOLONE CHYMASE INHIBITORS

Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.