Tetrahedron p. 1453 - 1464 (1989)
Update date:2022-08-05
Topics:
Baldwin, Jack E.
North, Michael
Flinn, Anthony
Moloney, Mark G.
The synthesis of α-t-butyl γ-methyl N-trityl-(S)-glutamate (12) from (S)-glutamic acid (6) is described.Diester (12), on treatment with lithium isopropylcyclohexylamide followed by the addition of carbonyl compounds, reacts to give the γ-substituted glutamic acid derivatives (13a-i) with retention of optical purity at the α centre.
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Doi:10.1021/ja107444m
(2010)Doi:10.1039/c2jm34817a
(2012)Doi:10.1055/s-1989-27274
(1989)Doi:10.1039/c003382k
(2010)Doi:10.1002/ejoc.201000355
(2010)Doi:10.1016/j.ejmech.2010.07.023
(2010)