Organic Process Research and Development p. 1200 - 1207 (2018)
Update date:2022-07-30
Topics:
Feng, Wei-Dong
Zhuo, Song-Ming
Yu, Jun
Zhao, Chuan-Meng
Zhang, Fu-Li
An efficient and robust synthetic route to (+)-ambrisentan ((+)-AMB) was designed by recycling the unwanted isomer from the resolution mother liquors. The racemization of AMB in the absence of either acid or base in the given solvents was reported. The recovery process was developed to produce racemates with purities over 99.5%. The mechanism of the formation of the process-related impurities of (+)-AMB is also discussed in detail. (+)-AMB was obtained in 47% overall yield with >99.5% purity and 99.8% e.e. by chiral resolution with only one recycling of the mother liquors on a 100-g scale without column purification.
View MoreShandong Xingshun New Material Co., Ltd.
website:http://www.sd-xingshun.com
Contact:+86-519-86461196/+86-519-86464994
Address:Middle of Luhua East Road, Dingtao District
Contact:+86 21 34123252
Address:14, 4580 Dushi, Shanghai, China
Changzhou Baolong Chemical Industrial Co.,Ltd
website:http://www.czbaolong.com
Contact:0519-85720726 0519-85720721 13951213302
Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
Tianjin Puck Rice Chemicals Co., Ltd.
Contact:022-58054572
Address:Weidi Road
Anhui Redstar Pharmaceutical Corp., Ltd
Contact:+86-563-5120837
Address:Jingxian Industrial Development Zone, Anhui , China
Doi:10.1039/c1ob05748k
(2011)Doi:10.1021/acs.joc.6b02697
(2017)Doi:10.1021/acs.orglett.7b03950
(2018)Doi:10.1016/S0040-4039(00)74863-5
(1991)Doi:10.1039/c39910000269
(1991)Doi:10.1021/ja00011a004
(1991)