10.1002/cbic.201800170
ChemBioChem
COMMUNICATION
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Experimental Section
All synthetic procedures, characterisation data for all new compounds (1H
&
13C NMR, HPLC, LC-MS, HRMS) and biophysical techniques (FP and
DSF assays, ITC, and molecular modelling) are detailed in the ESI.†
Acknowledgements
We would like to acknowledge Cancer Research UK
(C9344/A10268) (GW), the BBSRC (BB/L01923X/1) (GW), the
Bloomsbury Consortium (NDG, GW), UCL Knowledge Exchange
and Innovation Fund (NDG, GW), Maplethorpe Fellowship (NDG),
MRC Proximity to Discovery (ST, JG, FK) and UCL School of
Pharmacy (GW, FK) for financial support. HRMS were obtained
from the EPSRC UK National Mass Spectrometry Facility (NMSF)
at Swansea University.
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Conflict of interest
GW, JG and NDG are founders of Keregen Therapeutics Ltd, an
SME with an interest in developing small molecule inducers of
Nrf2.
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Biosyst 2016, 12, 1378-1387.
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Tanaka, M. Yamamoto, Nat. Cell Biol. 2010, 12, 213-223; d. Y. Ichimura,
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Keywords: Keap1 • Nrf2 • peptides • unnatural amino acids •
protein-protein interaction
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