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Diastereo- and Enantioselective Synthesis of Fluorinated Proline Derivatives
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HRMS (ESI): m/z [M + H+] calcd for C14H18F3N2O2: 303.1315;
(8) For reviews on the asymmetric construction of stereogenic
found: 303.1315.
carbon centers featuring a trifluoromethyl group, see:
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HPLC (Lux Amylose-2; hexane–i-PrOH, 80:20; flow rate = 0.7
mL/min): tR = 15.2 min (major), 19.1 min (minor).
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Supporting Information for this article is available online at
Acknowledgment
This work was financially supported by the Major Basic Research
Development Program (2010CB833300), the National Natural Sci-
ence Foundation of China (20872161, 20821002, 21032007), the
Chinese Academy of Sciences, the External Cooperation Program
of CAS (GJHZ200816), and the Technology Commission of Shang-
hai Municipality. A grant from the Austrian Exchange Service (Nr.
VII.B.16) is kindly acknowledged.
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