Journal of the Chemical Society. Perkin transactions I p. 2939 - 2944 (1993)
Update date:2022-08-05
Topics:
Cadamuro, Silvano
Degani, Iacopo
Fochi, Rita
Gatti, Antonella
Piscopo, Laura
A new general method for the synthesis of pyrrole-2,5-dicarbaldehyde and its 3-mono- and 3,4-disubstituted derivatives is reported.It involves the intermediate formation of the corresponding 2,5-bis(1,3-benzodithiol-2-yl)pyrroles followed by hydrolysis with HgO-35percent aq.HBF4-DMSO.Pyrrole-2,5-dicarbaldehyde was obtained in overall yields of 43-65percent, whilst that of the derivatives was 32-90percent.Moreover the methylation of the corresponding dithiolic intermediate with further hydrolysis resulted in the formation of 1-methylpyrrole-2,5-dicarbaldehyde in 90percent overall yield.
View MoreContact:+86-21-61318535
Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
Shandong Topscience Biotech Co., Ltd.
Contact:0633-2619278
Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Zhejiang Newfine Industry Co.,Ltd.
Contact:+86-573-82262042
Address:No.225,Dongqing Road, garoms@163.com
Contact:852-27701081
Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK
Nanjing chemipioneer pharmaceutical & technology Co., LTD
website:http://www.chemipioneer.com.cn
Contact:+86-25-52685700
Address:Room 305,A Block,Biological-Medicine Building,Business Start-up Center,Xin-ke 1st Road, High-tech development zone,Nanjing city,Jiangsu Province, China
Doi:10.1016/S0040-4020(01)80558-5
(1993)Doi:10.1016/S0040-4039(00)61673-8
(1993)Doi:10.1016/S0040-4039(00)81886-9
(1983)Doi:10.1246/cl.1981.843
(1981)Doi:10.1039/c6cc09451a
(2017)Doi:10.1016/j.saa.2011.10.023
(2012)