Nucleosides and Nucleotides p. 883 - 889 (1994)
Update date:2022-08-05
Topics:
Fossey
Laduree
Robba
A series of thieno[3,2-d]pyrimidine-2,4-diones alkylated with acyclic chains have been synthesized related to the antiherpetic agents (acyclovir and ganciclovir) and to EBPU which was reported to display in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1). Conversion of the hydroxy-acyclic nucleosides into their azido derivatives was then examined using triphenylphosphine - carbon tetraiodide - sodium azide. All the compounds, however, did not exhibit any significant inhibitory activity against HIV-1 in CEM cl 13 cells.
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Doi:10.1039/c3cc49488h
(2014)Doi:10.1080/15257779408011886
(1994)Doi:10.1021/jo01149a035
(1950)Doi:10.1039/c9ra00972h
(2019)Doi:10.1021/ic4025876
(2014)Doi:10.1021/jo01016a002
(1965)