Journal of labelled compounds and radiopharmaceuticals p. 1145 - 1163 (1998)
Update date:2022-08-05
Topics:
Baldwin, Jack E.
Adlington, Robert M.
Crouch, Nicholas P.
Pereira, Ines A.C.
The preparation of isotopically labelled penicillin Ns using a chemico-enzymatic approach is described. This route involves the chemical synthesis of variously labelled D,L,D,-aminoadipoyl-cysteinyl-valine tripeptides via well established facile protocols and concludes with the conversion of these tripeptides directly into penicillin Ns by the action of recombinant isopenicillin N synthase. Milligram quantities of isotopically labelled penicillin Ns, which would otherwise represent very challenging and expensive synthetic targets, are readily accessible from this route.
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