Synthetic Communications p. 1095 - 1102 (2000)
Update date:2022-08-05
Topics:
Davies, Antony J.
Ashwood, Michael S.
Cottrell, Ian F.
A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.
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