Tetrahedron Letters p. 6915 - 6918 (2001)
Update date:2022-08-04
Topics:
Sasaki, Shigeki
Yamauchi, Hiroyuki
Nagatsugi, Fumi
Takahashi, Ryo
Taniguchi, Yosuke
Maeda, Minoru
Novel nucleoside analogs have been designed for selective formation of anti-parallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7βG, formed a stable triplex with high selectivity to the TA site.
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